Nuclear Magnetic Resonance (NMR)

  1. Two-Dimensional NMR Spectroscopy
    1. 2D NMR Principles
      1. Pulse Sequence Structure
        1. Preparation Period
          1. Evolution Period (t₁)
            1. Mixing Period
              1. Detection Period (t₂)
              2. Data Acquisition
                1. Incremental Evolution Times
                  1. Phase Cycling
                    1. Quadrature Detection
                    2. Data Processing
                      1. 2D Fourier Transform
                        1. Phase Correction
                          1. Baseline Correction
                            1. Peak Picking
                            2. Spectrum Interpretation
                              1. Diagonal Peaks
                                1. Cross Peaks
                                  1. Contour Plots
                                    1. Peak Intensities
                                  2. Homonuclear 2D Experiments
                                    1. COSY (Correlation Spectroscopy)
                                      1. Through-Bond Correlations
                                        1. Spin System Identification
                                          1. Coupling Network Mapping
                                          2. DQF-COSY (Double Quantum Filtered COSY)
                                            1. Improved Resolution
                                              1. Artifact Suppression
                                                1. Phase Properties
                                                2. TOCSY (Total Correlation Spectroscopy)
                                                  1. Spin System Connectivity
                                                    1. Mixing Time Optimization
                                                      1. Complete Correlation Networks
                                                      2. NOESY (Nuclear Overhauser Effect Spectroscopy)
                                                        1. Through-Space Correlations
                                                          1. Distance Information
                                                            1. Conformational Analysis
                                                              1. Exchange Processes
                                                              2. ROESY (Rotating Frame Overhauser Effect Spectroscopy)
                                                                1. Medium-Sized Molecules
                                                                  1. Spin Diffusion Suppression
                                                                    1. Chemical Exchange
                                                                  2. Heteronuclear 2D Experiments
                                                                    1. HSQC (Heteronuclear Single Quantum Coherence)
                                                                      1. One-Bond Correlations
                                                                        1. Sensitivity Enhancement
                                                                          1. Multiplicity Editing
                                                                          2. HMQC (Heteronuclear Multiple Quantum Coherence)
                                                                            1. Alternative to HSQC
                                                                              1. Phase Properties
                                                                                1. Artifact Patterns
                                                                                2. HMBC (Heteronuclear Multiple Bond Correlation)
                                                                                  1. Long-Range Correlations
                                                                                    1. Quaternary Carbon Detection
                                                                                      1. Structural Connectivity
                                                                                      2. HSQC-TOCSY
                                                                                        1. Combined Experiments
                                                                                          1. Extended Correlation Networks
                                                                                            1. Assignment Strategies

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                                                                                        7. Advanced One-Dimensional Techniques

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                                                                                        9. Multinuclear NMR