Nuclear Magnetic Resonance (NMR)

  1. NMR Applications and Problem Solving
    1. Structure Elucidation Strategies
      1. Systematic Approach
        1. Molecular Formula Determination
          1. Functional Group Identification
            1. Connectivity Analysis
              1. Stereochemical Assignment
              2. Integration of Techniques
                1. 1D and 2D NMR Combination
                  1. Multinuclear Approaches
                    1. Complementary Methods
                    2. Database and Literature Searching
                      1. Spectral Databases
                        1. Chemical Shift Prediction
                          1. Literature Precedents
                        2. Mixture Analysis
                          1. Component Identification
                            1. Peak Assignment
                              1. Integration Analysis
                                1. Selective Experiments
                                2. Quantitative Analysis
                                  1. Internal Standards
                                    1. Calibration Curves
                                      1. Method Validation
                                      2. Dynamic Mixtures
                                        1. Exchange Processes
                                          1. Equilibrium Studies
                                            1. Kinetic Analysis
                                          2. Purity Assessment
                                            1. Impurity Detection
                                              1. Sensitivity Limits
                                                1. Identification Strategies
                                                  1. Quantification Methods
                                                  2. Water Content Determination
                                                    1. Karl Fischer Comparison
                                                      1. Integration Methods
                                                        1. Solvent Effects
                                                        2. Residual Solvents
                                                          1. ICH Guidelines
                                                            1. Quantitative Methods
                                                              1. Method Development
                                                            2. Reaction Monitoring
                                                              1. Real-Time NMR
                                                                1. Flow Systems
                                                                  1. In-Situ Monitoring
                                                                    1. Kinetic Studies
                                                                    2. Mechanistic Studies
                                                                      1. Intermediate Detection
                                                                        1. Pathway Elucidation
                                                                          1. Catalyst Studies
                                                                          2. Optimization Studies
                                                                            1. Reaction Conditions
                                                                              1. Yield Determination
                                                                                1. Side Product Analysis

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                                                                            10. Specialized NMR Techniques

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                                                                            12. Magnetic Resonance Imaging (MRI)