Instrumental Chemistry

  1. Hyphenated Techniques
    1. Concept of Coupling Separation and Detection
      1. Advantages of Hyphenated Techniques
        1. Enhanced Selectivity
          1. Structural Information
            1. Reduced Sample Preparation
            2. Challenges in Coupling
              1. Flow Rate Compatibility
                1. Solvent Compatibility
                  1. Interface Design
                    1. Data Handling
                  2. Gas Chromatography-Mass Spectrometry
                    1. Interface Design
                      1. Direct Coupling
                        1. Jet Separators
                          1. Membrane Separators
                          2. Operating Conditions
                            1. Carrier Gas Selection
                              1. Temperature Programming
                                1. Ionization Methods
                                2. Data Interpretation
                                  1. Chromatographic Separation
                                    1. Mass Spectral Identification
                                      1. Library Searching
                                      2. Applications
                                        1. Environmental Analysis
                                          1. Forensic Analysis
                                            1. Metabolomics
                                          2. Liquid Chromatography-Mass Spectrometry
                                            1. Interface Design
                                              1. Electrospray Ionization
                                                1. Atmospheric Pressure Chemical Ionization
                                                  1. Atmospheric Pressure Photoionization
                                                  2. Mobile Phase Considerations
                                                    1. Volatile Buffers
                                                      1. Organic Modifiers
                                                        1. Flow Rate Optimization
                                                        2. Method Development
                                                          1. Chromatographic Optimization
                                                            1. MS Parameter Optimization
                                                              1. Matrix Effects
                                                              2. Applications
                                                                1. Pharmaceutical Analysis
                                                                  1. Proteomics
                                                                    1. Metabolomics
                                                                  2. Tandem Mass Spectrometry
                                                                    1. Principles of MS/MS
                                                                      1. Precursor Ion Selection
                                                                        1. Fragmentation Methods
                                                                          1. Product Ion Analysis
                                                                          2. Instrumentation
                                                                            1. Triple Quadrupole Systems
                                                                              1. Ion Trap Systems
                                                                                1. Hybrid Instruments
                                                                                2. Scan Modes
                                                                                  1. Product Ion Scan
                                                                                    1. Precursor Ion Scan
                                                                                      1. Neutral Loss Scan
                                                                                        1. Selected Reaction Monitoring
                                                                                        2. Applications
                                                                                          1. Quantitative Analysis
                                                                                            1. Structural Elucidation
                                                                                              1. Biomarker Discovery

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                                                                                          5. Separation Science and Chromatography

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                                                                                          7. Electrochemical Methods