Population Genetics

  1. The Hardy-Weinberg Principle
    1. Theoretical Foundation
      1. Null Model Concept
        1. Purpose in Population Genetics
          1. Predictive Framework
          2. Mathematical Formulation
            1. Single Locus with Two Alleles
              1. p + q = 1
                1. p² + 2pq + q² = 1
                2. Multiple Alleles
                  1. Extension of Basic Equation
                    1. Multinomial Expansion
                    2. Multiple Loci
                      1. Independent Assortment
                        1. Linkage Considerations
                      2. Assumptions
                        1. No Mutation
                          1. No Natural Selection
                            1. No Gene Flow
                              1. Random Mating
                                1. Large Population Size
                                  1. No Meiotic Drive
                                  2. Applications
                                    1. Predicting Genotype Frequencies
                                      1. Testing for Evolutionary Forces
                                        1. Carrier Frequency Estimation
                                          1. Medical Genetics Applications
                                          2. Testing Hardy-Weinberg Equilibrium
                                            1. Chi-Square Goodness of Fit
                                              1. Exact Tests
                                                1. Interpreting Deviations
                                                  1. Sources of Error

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                                                2. Genetic Variation in Populations

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                                                4. Mutation as an Evolutionary Force