Microbiology and Immunology

  1. Immunopathology
    1. Hypersensitivity Reactions
      1. Type I Hypersensitivity
        1. IgE-Mediated Reactions
          1. Mast Cell Degranulation
            1. Anaphylaxis
              1. Allergic Diseases
              2. Type II Hypersensitivity
                1. Antibody-Mediated Cytotoxicity
                  1. Complement-Mediated Lysis
                    1. Antibody-Dependent Cellular Cytotoxicity
                    2. Type III Hypersensitivity
                      1. Immune Complex Formation
                        1. Complement Activation
                          1. Tissue Damage
                          2. Type IV Hypersensitivity
                            1. T-Cell Mediated Reactions
                              1. Delayed-Type Hypersensitivity
                                1. Contact Hypersensitivity
                              2. Autoimmune Diseases
                                1. Mechanisms of Autoimmunity
                                  1. Loss of Self-Tolerance
                                    1. Molecular Mimicry
                                      1. Epitope Spreading
                                      2. Genetic Factors
                                        1. HLA Associations
                                          1. Non-HLA Genes
                                            1. Gene-Environment Interactions
                                            2. Organ-Specific Autoimmunity
                                              1. Type 1 Diabetes
                                                1. Multiple Sclerosis
                                                  1. Myasthenia Gravis
                                                  2. Systemic Autoimmunity
                                                    1. Systemic Lupus Erythematosus
                                                      1. Rheumatoid Arthritis
                                                        1. Systemic Sclerosis
                                                      2. Immunodeficiency Disorders
                                                        1. Primary Immunodeficiencies
                                                          1. B-Cell Deficiencies
                                                            1. T-Cell Deficiencies
                                                              1. Combined Immunodeficiencies
                                                                1. Phagocyte Defects
                                                                  1. Complement Deficiencies
                                                                  2. Secondary Immunodeficiencies
                                                                    1. Acquired Immunodeficiency Syndrome
                                                                      1. Malnutrition
                                                                        1. Immunosuppressive Therapy
                                                                          1. Aging
                                                                          2. Clinical Manifestations
                                                                            1. Recurrent Infections
                                                                              1. Opportunistic Infections
                                                                                1. Malignancies
                                                                                  1. Autoimmune Phenomena

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                                                                              11. Host-Pathogen Interactions

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                                                                              13. Clinical Applications