Gene Regulation

  1. Gene Regulation in Development and Disease
    1. Developmental Gene Regulation
      1. Early Embryonic Patterning
        1. Maternal Effect Genes
          1. Zygotic Gene Activation
            1. Body Axis Establishment
            2. Segmentation and Patterning
              1. Gap Genes
                1. Pair-Rule Genes
                  1. Segment Polarity Genes
                    1. Homeotic Genes
                    2. Hox Gene Regulation
                      1. Hox Gene Clusters
                        1. Collinearity Principle
                          1. Chromatin Domains
                            1. Posterior Prevalence
                            2. Cell Fate Specification
                              1. Lineage-Specific Transcription Factors
                                1. Signaling Pathway Integration
                                  1. Epigenetic Memory Establishment
                                  2. Stem Cell Regulation
                                    1. Pluripotency Networks
                                      1. Self-Renewal Mechanisms
                                        1. Differentiation Triggers
                                          1. Niche Signaling
                                        2. Disease-Associated Dysregulation
                                          1. Cancer Gene Regulation
                                            1. Oncogene Activation
                                              1. Growth Factor Receptors
                                                1. Signal Transduction Proteins
                                                  1. Transcription Factors
                                                  2. Tumor Suppressor Inactivation
                                                    1. Cell Cycle Checkpoints
                                                      1. DNA Repair Genes
                                                        1. Apoptosis Regulators
                                                        2. Epigenetic Alterations
                                                          1. DNA Hypermethylation
                                                            1. Histone Modification Changes
                                                              1. Chromatin Remodeling Defects
                                                              2. MicroRNA Dysregulation
                                                                1. Oncogenic miRNAs
                                                                  1. Tumor Suppressor miRNAs
                                                                2. Genetic Disorders
                                                                  1. Trinucleotide Repeat Expansions
                                                                    1. Huntington's Disease
                                                                      1. Fragile X Syndrome
                                                                        1. Myotonic Dystrophy
                                                                        2. Imprinting Disorders
                                                                          1. Beckwith-Wiedemann Syndrome
                                                                            1. Prader-Willi Syndrome
                                                                              1. Angelman Syndrome
                                                                              2. Transcription Factor Mutations
                                                                                1. Developmental Disorders
                                                                                  1. Metabolic Diseases
                                                                                2. Aging and Gene Regulation
                                                                                  1. Epigenetic Drift
                                                                                    1. Telomere Shortening Effects
                                                                                      1. Cellular Senescence

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                                                                                  7. Translational and Post-Translational Control

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                                                                                  9. Experimental Approaches to Gene Regulation