Gene Regulation

  1. Post-Transcriptional Regulation in Eukaryotes
    1. RNA Processing Control
      1. 5' End Capping
        1. Cap Structure Formation
          1. Capping Enzyme Complex
            1. Cap-Binding Proteins
              1. Translation Enhancement
              2. 3' End Processing
                1. Polyadenylation Signals
                  1. Cleavage and Polyadenylation Specificity Factor
                    1. Poly(A) Polymerase Activity
                      1. Poly(A) Tail Functions
                      2. Alternative Polyadenylation
                        1. Multiple Polyadenylation Sites
                          1. 3' UTR Length Regulation
                            1. miRNA Target Site Inclusion
                          2. Splicing Regulation
                            1. Spliceosome Assembly
                              1. snRNP Components
                                1. Splicing Catalysis
                                  1. Exon Junction Complex Formation
                                  2. Alternative Splicing Mechanisms
                                    1. Exon Skipping
                                      1. Intron Retention
                                        1. Alternative 5' Splice Sites
                                          1. Alternative 3' Splice Sites
                                            1. Mutually Exclusive Exons
                                            2. Splicing Regulatory Elements
                                              1. Exonic Splicing Enhancers
                                                1. Exonic Splicing Silencers
                                                  1. Intronic Splicing Enhancers
                                                    1. Intronic Splicing Silencers
                                                    2. Splicing Regulatory Proteins
                                                      1. SR Proteins
                                                        1. hnRNPs
                                                          1. Tissue-Specific Splicing Factors
                                                          2. Functional Consequences
                                                            1. Protein Isoform Generation
                                                              1. Nonsense-Mediated Decay Targeting
                                                                1. Regulatory Domain Inclusion
                                                              2. RNA Transport and Localization
                                                                1. Nuclear Export Mechanisms
                                                                  1. Nuclear Pore Complex
                                                                    1. Export Receptors
                                                                      1. Quality Control Checkpoints
                                                                      2. Cytoplasmic RNA Localization
                                                                        1. Localization Signals
                                                                          1. Motor Protein Transport
                                                                            1. Local Translation Control
                                                                          2. RNA Stability and Degradation
                                                                            1. mRNA Stability Determinants
                                                                              1. 5' Cap Protection
                                                                                1. Poly(A) Tail Protection
                                                                                  1. RNA-Binding Protein Effects
                                                                                  2. Deadenylation-Dependent Decay
                                                                                    1. Deadenylase Complexes
                                                                                      1. Poly(A) Tail Shortening
                                                                                        1. Decapping and Degradation
                                                                                        2. Nonsense-Mediated Decay
                                                                                          1. Premature Termination Codon Recognition
                                                                                            1. Exon Junction Complex Role
                                                                                              1. UPF Protein Functions
                                                                                              2. AU-Rich Element-Mediated Decay
                                                                                                1. ARE-Binding Proteins
                                                                                                  1. mRNA Destabilization
                                                                                                  2. miRNA-Mediated Decay
                                                                                                    1. RISC Complex Function
                                                                                                      1. Target Recognition
                                                                                                        1. Deadenylation and Degradation

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                                                                                                    4. Eukaryotic Transcriptional Regulation

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                                                                                                    6. RNA-Mediated Gene Regulation