Gene Regulation

  1. RNA-Mediated Gene Regulation
    1. Small Non-Coding RNAs
      1. MicroRNAs
        1. miRNA Gene Structure
          1. Primary Transcript Processing
            1. Drosha Cleavage
              1. Nuclear Processing
              2. Precursor miRNA Export
                1. Cytoplasmic Processing
                  1. Dicer Cleavage
                    1. Mature miRNA Generation
                    2. RISC Loading and Function
                      1. Argonaute Proteins
                        1. Target Recognition
                          1. Translational Repression
                            1. mRNA Degradation
                            2. Biological Functions
                              1. Developmental Timing
                                1. Cell Fate Specification
                                  1. Disease Associations
                                2. Small Interfering RNAs
                                  1. siRNA Origins
                                    1. Exogenous Sources
                                      1. Endogenous Generation
                                      2. Processing Pathways
                                        1. Dicer-Dependent Processing
                                          1. RISC Assembly
                                          2. Target Cleavage Mechanism
                                            1. Genome Defense Functions
                                              1. Viral Defense
                                                1. Transposon Silencing
                                              2. Piwi-Interacting RNAs
                                                1. piRNA Characteristics
                                                  1. Biogenesis Pathways
                                                    1. Primary Processing
                                                      1. Ping-Pong Amplification
                                                      2. Germline Functions
                                                        1. Transposon Silencing
                                                      3. Long Non-Coding RNAs
                                                        1. lncRNA Classification
                                                          1. Intergenic lncRNAs
                                                            1. Antisense lncRNAs
                                                              1. Intronic lncRNAs
                                                              2. Mechanisms of Action
                                                                1. Chromatin Modification Recruitment
                                                                  1. Transcriptional Interference
                                                                    1. Post-Transcriptional Regulation
                                                                      1. Protein Sequestration
                                                                      2. Functional Examples
                                                                        1. X-Chromosome Inactivation
                                                                          1. Genomic Imprinting
                                                                            1. Enhancer Function
                                                                          2. Other Regulatory RNAs
                                                                            1. Circular RNAs
                                                                              1. Biogenesis Mechanisms
                                                                                1. miRNA Sponge Function
                                                                                  1. Protein Interaction
                                                                                  2. Small Nucleolar RNAs
                                                                                    1. rRNA Modification
                                                                                      1. Ribosome Biogenesis
                                                                                      2. Transfer RNA Fragments
                                                                                        1. Stress Response Functions
                                                                                          1. Translation Regulation

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                                                                                      5. Post-Transcriptional Regulation in Eukaryotes

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                                                                                      7. Translational and Post-Translational Control