Excitable Cell Physiology

  1. Pathophysiology and Pharmacology
    1. Channelopathies
      1. Sodium Channelopathies
        1. Periodic Paralysis
          1. Myotonia
            1. Epilepsy Syndromes
              1. Cardiac Arrhythmias
              2. Potassium Channelopathies
                1. Long QT Syndrome
                  1. Episodic Ataxia
                    1. Hyperkalemic Periodic Paralysis
                    2. Calcium Channelopathies
                      1. Familial Hemiplegic Migraine
                        1. Episodic Ataxia Type 2
                          1. Malignant Hyperthermia
                          2. Chloride Channelopathies
                            1. Myotonia Congenita
                              1. Bartter Syndrome
                              2. Genetic Basis
                                1. Mutation Types
                                  1. Inheritance Patterns
                                    1. Genotype-Phenotype Correlations
                                    2. Clinical Manifestations
                                      1. Neurological Symptoms
                                        1. Cardiac Symptoms
                                          1. Muscular Symptoms
                                        2. Demyelinating Diseases
                                          1. Multiple Sclerosis
                                            1. Pathogenesis
                                              1. Autoimmune Destruction
                                                1. Oligodendrocyte Loss
                                                  1. Inflammation
                                                  2. Conduction Abnormalities
                                                    1. Conduction Block
                                                      1. Slowed Conduction
                                                        1. Safety Factor Reduction
                                                        2. Clinical Symptoms
                                                          1. Motor Dysfunction
                                                            1. Sensory Loss
                                                              1. Cognitive Impairment
                                                            2. Guillain-Barré Syndrome
                                                              1. Pathogenesis
                                                                1. Autoimmune Demyelination
                                                                  1. Schwann Cell Damage
                                                                    1. Molecular Mimicry
                                                                    2. Electrophysiological Changes
                                                                      1. Conduction Velocity Reduction
                                                                        1. Conduction Block
                                                                          1. Temporal Dispersion
                                                                          2. Clinical Course
                                                                            1. Ascending Paralysis
                                                                              1. Respiratory Involvement
                                                                                1. Recovery Patterns
                                                                            2. Pharmacological Agents
                                                                              1. Local Anesthetics
                                                                                1. Mechanism of Action
                                                                                  1. Sodium Channel Block
                                                                                    1. Use-Dependent Block
                                                                                      1. Binding Site
                                                                                      2. Clinical Applications
                                                                                        1. Nerve Blocks
                                                                                          1. Spinal Anesthesia
                                                                                            1. Topical Anesthesia
                                                                                            2. Structure-Activity Relationships
                                                                                              1. Lipophilicity
                                                                                                1. Protein Binding
                                                                                                  1. Duration of Action
                                                                                                2. Neurotoxins
                                                                                                  1. Tetrodotoxin
                                                                                                    1. Sodium Channel Block
                                                                                                      1. Puffer Fish Poisoning
                                                                                                        1. Research Applications
                                                                                                        2. Saxitoxin
                                                                                                          1. Paralytic Shellfish Poisoning
                                                                                                            1. Sodium Channel Block
                                                                                                            2. Batrachotoxin
                                                                                                              1. Persistent Channel Activation
                                                                                                                1. Poison Dart Frogs
                                                                                                              2. Antiepileptic Drugs
                                                                                                                1. Sodium Channel Modulators
                                                                                                                  1. Phenytoin
                                                                                                                    1. Carbamazepine
                                                                                                                      1. Lamotrigine
                                                                                                                      2. Calcium Channel Blockers
                                                                                                                        1. Ethosuximide
                                                                                                                          1. Gabapentin
                                                                                                                          2. GABA Modulators
                                                                                                                            1. Benzodiazepines
                                                                                                                              1. Barbiturates
                                                                                                                            2. Cardiac Drugs
                                                                                                                              1. Antiarrhythmic Agents
                                                                                                                                1. Class I (Sodium Channel Blockers)
                                                                                                                                  1. Class II (Beta Blockers)
                                                                                                                                    1. Class III (Potassium Channel Blockers)
                                                                                                                                      1. Class IV (Calcium Channel Blockers)
                                                                                                                                    2. Synaptic Modulators
                                                                                                                                      1. Neurotransmitter Agonists
                                                                                                                                        1. Cholinergic Agonists
                                                                                                                                          1. Adrenergic Agonists
                                                                                                                                          2. Neurotransmitter Antagonists
                                                                                                                                            1. Cholinergic Antagonists
                                                                                                                                              1. Adrenergic Antagonists
                                                                                                                                              2. Reuptake Inhibitors
                                                                                                                                                1. Selective Serotonin Reuptake Inhibitors
                                                                                                                                                  1. Norepinephrine Reuptake Inhibitors
                                                                                                                                                  2. Release Modulators
                                                                                                                                                    1. Botulinum Toxin
                                                                                                                                                      1. Alpha-Latrotoxin

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                                                                                                                                                8. Sensory Transduction

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                                                                                                                                                1. Foundations of Membrane Bioelectricity