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Engineering
Biomedical Engineering
Biomaterials and Tissue Engineering
1. Introduction to Biomaterials and Tissue Engineering
2. Materials Science Fundamentals
3. Classes of Biomaterials
4. Cell Biology for Tissue Engineering
5. Cell Sources for Tissue Engineering
6. Extracellular Matrix
7. Growth Factors and Signaling
8. Biocompatibility and Host Response
9. Scaffold Design and Engineering
10. Bioreactor Systems
11. Characterization Methods
12. Tissue Engineering Applications
13. Drug Delivery Systems
14. Medical Device Applications
15. Regulatory and Clinical Translation
16. Emerging Technologies and Future Directions
8.
Biocompatibility and Host Response
8.1.
Biocompatibility Concepts
8.1.1.
Definition and Scope
8.1.2.
Factors Affecting Biocompatibility
8.1.2.1.
Material Properties
8.1.2.2.
Host Factors
8.1.2.3.
Application Site
8.1.3.
Testing Standards
8.2.
Protein Adsorption
8.2.1.
Protein-Surface Interactions
8.2.2.
Vroman Effect
8.2.3.
Protein Conformation Changes
8.2.4.
Competitive Adsorption
8.3.
Cellular Response
8.3.1.
Initial Cell Contact
8.3.2.
Cell Adhesion
8.3.3.
Cell Spreading
8.3.4.
Cell Activation
8.4.
Immune Response
8.4.1.
Innate Immunity
8.4.1.1.
Complement Activation
8.4.1.2.
Macrophage Response
8.4.1.3.
Neutrophil Activation
8.4.2.
Adaptive Immunity
8.4.2.1.
T Cell Response
8.4.2.2.
B Cell Response
8.4.2.3.
Antibody Production
8.5.
Inflammatory Response
8.5.1.
Acute Inflammation
8.5.1.1.
Vascular Changes
8.5.1.2.
Cellular Events
8.5.1.3.
Mediators
8.5.2.
Chronic Inflammation
8.5.2.1.
Persistent Stimuli
8.5.2.2.
Tissue Damage
8.5.2.3.
Resolution
8.6.
Foreign Body Response
8.6.1.
Sequence of Events
8.6.2.
Foreign Body Giant Cells
8.6.3.
Fibrous Capsule Formation
8.6.4.
Factors Influencing Response
8.7.
Blood Compatibility
8.7.1.
Hemolysis
8.7.2.
Platelet Activation
8.7.3.
Coagulation
8.7.4.
Complement Activation
8.8.
Biocompatibility Testing
8.8.1.
In Vitro Tests
8.8.1.1.
Cytotoxicity Assays
8.8.1.2.
Hemolysis Tests
8.8.1.3.
Complement Activation
8.8.2.
In Vivo Tests
8.8.2.1.
Implantation Studies
8.8.2.2.
Systemic Toxicity
8.8.2.3.
Carcinogenicity
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7. Growth Factors and Signaling
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9. Scaffold Design and Engineering