Biomaterials and Tissue Engineering

  1. Biocompatibility and Host Response
    1. Biocompatibility Concepts
      1. Definition and Scope
        1. Factors Affecting Biocompatibility
          1. Material Properties
            1. Host Factors
              1. Application Site
              2. Testing Standards
              3. Protein Adsorption
                1. Protein-Surface Interactions
                  1. Vroman Effect
                    1. Protein Conformation Changes
                      1. Competitive Adsorption
                      2. Cellular Response
                        1. Initial Cell Contact
                          1. Cell Adhesion
                            1. Cell Spreading
                              1. Cell Activation
                              2. Immune Response
                                1. Innate Immunity
                                  1. Complement Activation
                                    1. Macrophage Response
                                      1. Neutrophil Activation
                                      2. Adaptive Immunity
                                        1. T Cell Response
                                          1. B Cell Response
                                            1. Antibody Production
                                          2. Inflammatory Response
                                            1. Acute Inflammation
                                              1. Vascular Changes
                                                1. Cellular Events
                                                  1. Mediators
                                                  2. Chronic Inflammation
                                                    1. Persistent Stimuli
                                                      1. Tissue Damage
                                                        1. Resolution
                                                      2. Foreign Body Response
                                                        1. Sequence of Events
                                                          1. Foreign Body Giant Cells
                                                            1. Fibrous Capsule Formation
                                                              1. Factors Influencing Response
                                                              2. Blood Compatibility
                                                                1. Hemolysis
                                                                  1. Platelet Activation
                                                                    1. Coagulation
                                                                      1. Complement Activation
                                                                      2. Biocompatibility Testing
                                                                        1. In Vitro Tests
                                                                          1. Cytotoxicity Assays
                                                                            1. Hemolysis Tests
                                                                              1. Complement Activation
                                                                              2. In Vivo Tests
                                                                                1. Implantation Studies
                                                                                  1. Systemic Toxicity
                                                                                    1. Carcinogenicity

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                                                                                7. Growth Factors and Signaling

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                                                                                9. Scaffold Design and Engineering