Systems Biology

9.

Single-Cell Systems Biology

9.1.

Single-Cell Technologies

9.1.1.

Single-Cell RNA Sequencing

9.1.1.1.

Cell Isolation Methods

9.1.1.2.

Library Preparation

9.1.1.3.

Data Analysis Pipelines

9.1.2.

Single-Cell Proteomics

9.1.2.1.

9.1.2.2.

9.1.2.3.

Imaging Mass Cytometry

9.1.3.

Single-Cell Genomics

9.1.3.1.

Single-Cell DNA Sequencing

9.1.3.2.

Single-Cell ATAC-Seq

9.1.3.3.

Single-Cell Hi-C

9.2.

Cellular Heterogeneity Analysis

9.2.1.

Sources of Heterogeneity

9.2.1.1.

Intrinsic Noise

9.2.1.2.

Extrinsic Variability

9.2.1.3.

Cell Cycle Effects

9.2.2.

Dimensionality Reduction

9.2.2.1.

9.2.2.2.

9.2.2.3.

9.2.3.

Clustering and Classification

9.2.3.1.

Community Detection

9.2.3.2.

Cell Type Identification

9.2.3.3.

Rare Cell Detection

9.3.

Developmental Trajectories

9.3.1.

Pseudotime Analysis

9.3.1.1.

Trajectory Inference

9.3.1.2.

Branch Point Detection

9.3.1.3.

Temporal Ordering

9.3.2.

Lineage Tracing

9.3.2.1.

Experimental Approaches

9.3.2.2.

Computational Reconstruction

9.3.2.3.

9.3.3.

Cell State Transitions

9.3.3.1.

Differentiation Dynamics

9.3.3.2.

9.3.3.3.

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10. Applications in Systems Medicine