Systems Biology

  1. Drug Discovery and Development
    1. Systems Pharmacology
      1. Drug-Target Networks
        1. Polypharmacology
          1. Off-Target Effects
            1. Drug Repurposing
            2. Pharmacokinetic Modeling
              1. ADMET Properties
                1. Physiologically-Based Models
                  1. Population Pharmacokinetics
                  2. Pharmacodynamic Modeling
                    1. Dose-Response Relationships
                      1. Mechanism-Based Models
                        1. Biomarker-Response Models
                      2. Target Identification and Validation
                        1. Network-Based Target Discovery
                          1. Essential Gene Analysis
                            1. Druggability Assessment
                              1. Target Prioritization
                              2. Experimental Validation
                                1. Functional Assays
                                  1. Animal Models
                                    1. Clinical Validation
                                  2. Drug Design and Optimization
                                    1. Structure-Based Drug Design
                                      1. Molecular Docking
                                        1. Virtual Screening
                                          1. Lead Optimization
                                          2. Systems-Based Design
                                            1. Network Pharmacology
                                              1. Multi-Target Drugs
                                                1. Combination Therapy Design
                                              2. Clinical Trial Design
                                                1. Biomarker-Driven Trials
                                                  1. Patient Stratification
                                                    1. Companion Diagnostics
                                                      1. Adaptive Designs
                                                      2. Systems Medicine Approaches
                                                        1. Precision Medicine
                                                          1. Personalized Dosing
                                                            1. Treatment Response Prediction

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                                                        10. Applications in Systems Medicine

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                                                        12. Synthetic Biology