Systems Biology

  1. Applications in Systems Medicine
    1. Cancer Systems Biology
      1. Tumor Heterogeneity
        1. Clonal Evolution
          1. Tumor Microenvironment
            1. Metastasis Modeling
            2. Driver Mutation Analysis
              1. Oncogenes and Tumor Suppressors
                1. Mutational Signatures
                  1. Pathway Alterations
                  2. Drug Resistance Mechanisms
                    1. Acquired Resistance
                      1. Intrinsic Resistance
                        1. Combination Therapy
                        2. Personalized Cancer Treatment
                          1. Biomarker Discovery
                            1. Treatment Response Prediction
                              1. Precision Oncology
                            2. Infectious Disease Modeling
                              1. Host-Pathogen Interactions
                                1. Immune Response Dynamics
                                  1. Pathogen Evolution
                                    1. Virulence Factors
                                    2. Epidemiological Models
                                      1. Compartmental Models
                                        1. Network-Based Spread
                                          1. Intervention Strategies
                                          2. Antimicrobial Resistance
                                            1. Resistance Mechanisms
                                              1. Evolution of Resistance
                                                1. Stewardship Strategies
                                              2. Neurological Disorders
                                                1. Neurodegenerative Diseases
                                                  1. Protein Aggregation
                                                    1. Neuronal Death Pathways
                                                      1. Therapeutic Targets
                                                      2. Psychiatric Disorders
                                                        1. Neurotransmitter Systems
                                                          1. Brain Network Dysfunction
                                                            1. Treatment Response
                                                            2. Brain Network Analysis
                                                              1. Connectome Mapping
                                                                1. Functional Networks
                                                                  1. Network Disruptions

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                                                              9. Single-Cell Systems Biology

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                                                              11. Drug Discovery and Development