Stroke and Neurological Disorders

  1. Other Major Neurological Disorders
    1. Epilepsy and Seizure Disorders
      1. Epidemiology
        1. Prevalence and Incidence
          1. Age Distribution
            1. Geographic Variations
              1. Socioeconomic Impact
              2. Seizure Classification
                1. Focal Seizures
                  1. Focal Aware Seizures
                    1. Motor Symptoms
                      1. Non-Motor Symptoms
                      2. Focal Impaired Awareness Seizures
                        1. Temporal Lobe Seizures
                          1. Extratemporal Seizures
                          2. Focal to Bilateral Tonic-Clonic Seizures
                          3. Generalized Seizures
                            1. Absence Seizures
                              1. Typical Absence
                                1. Atypical Absence
                                2. Tonic-Clonic Seizures
                                  1. Tonic Phase
                                    1. Clonic Phase
                                    2. Myoclonic Seizures
                                      1. Juvenile Myoclonic Epilepsy
                                        1. Progressive Myoclonic Epilepsies
                                        2. Atonic Seizures
                                          1. Drop Attacks
                                          2. Tonic Seizures
                                            1. Clonic Seizures
                                            2. Unknown Onset Seizures
                                              1. Motor Seizures
                                                1. Non-Motor Seizures
                                              2. Epilepsy Syndromes
                                                1. Genetic Epilepsy Syndromes
                                                  1. Dravet Syndrome
                                                    1. Lennox-Gastaut Syndrome
                                                      1. West Syndrome
                                                      2. Structural Epilepsies
                                                        1. Mesial Temporal Sclerosis
                                                          1. Cortical Dysplasia
                                                          2. Metabolic Epilepsies
                                                            1. Glucose Transporter Deficiency
                                                              1. Mitochondrial Disorders
                                                              2. Immune Epilepsies
                                                                1. Anti-NMDA Receptor Encephalitis
                                                                  1. Rasmussen's Encephalitis
                                                                2. Etiology and Pathophysiology
                                                                  1. Genetic Factors
                                                                    1. Ion Channel Mutations
                                                                      1. Neurotransmitter Receptor Mutations
                                                                        1. Developmental Gene Mutations
                                                                        2. Structural Abnormalities
                                                                          1. Cortical Malformations
                                                                            1. Hippocampal Sclerosis
                                                                              1. Vascular Malformations
                                                                                1. Tumors
                                                                                2. Metabolic Causes
                                                                                  1. Electrolyte Imbalances
                                                                                    1. Hypoglycemia
                                                                                      1. Uremia
                                                                                        1. Hepatic Encephalopathy
                                                                                        2. Infectious Causes
                                                                                          1. Meningitis
                                                                                            1. Encephalitis
                                                                                              1. Brain Abscess
                                                                                                1. Parasitic Infections
                                                                                                2. Traumatic Causes
                                                                                                  1. Post-Traumatic Epilepsy
                                                                                                    1. Penetrating Head Injury
                                                                                                    2. Toxic Causes
                                                                                                      1. Drug Withdrawal
                                                                                                        1. Alcohol Withdrawal
                                                                                                          1. Medication-Induced
                                                                                                        2. Clinical Presentation
                                                                                                          1. Ictal Phenomena
                                                                                                            1. Motor Manifestations
                                                                                                              1. Sensory Manifestations
                                                                                                                1. Autonomic Manifestations
                                                                                                                  1. Psychic Manifestations
                                                                                                                  2. Aura
                                                                                                                    1. Sensory Aura
                                                                                                                      1. Motor Aura
                                                                                                                        1. Autonomic Aura
                                                                                                                          1. Psychic Aura
                                                                                                                          2. Postictal State
                                                                                                                            1. Confusion
                                                                                                                              1. Fatigue
                                                                                                                                1. Focal Deficits
                                                                                                                                  1. Todd's Paralysis
                                                                                                                                2. Diagnostic Evaluation
                                                                                                                                  1. Clinical History
                                                                                                                                    1. Seizure Description
                                                                                                                                      1. Precipitating Factors
                                                                                                                                        1. Family History
                                                                                                                                          1. Developmental History
                                                                                                                                          2. Physical Examination
                                                                                                                                            1. Neurological Examination
                                                                                                                                              1. Skin Examination
                                                                                                                                                1. Dysmorphic Features
                                                                                                                                                2. Electroencephalography
                                                                                                                                                  1. Routine EEG
                                                                                                                                                    1. Sleep-Deprived EEG
                                                                                                                                                      1. Ambulatory EEG
                                                                                                                                                        1. Video-EEG Monitoring
                                                                                                                                                          1. Intracranial EEG
                                                                                                                                                          2. Neuroimaging
                                                                                                                                                            1. MRI Brain
                                                                                                                                                              1. Structural Abnormalities
                                                                                                                                                                1. Hippocampal Sclerosis
                                                                                                                                                                  1. Cortical Dysplasia
                                                                                                                                                                  2. Functional Imaging
                                                                                                                                                                    1. PET Scan
                                                                                                                                                                      1. SPECT Scan
                                                                                                                                                                        1. fMRI
                                                                                                                                                                      2. Laboratory Studies
                                                                                                                                                                        1. Routine Blood Tests
                                                                                                                                                                          1. Genetic Testing
                                                                                                                                                                            1. CSF Analysis
                                                                                                                                                                              1. Metabolic Studies
                                                                                                                                                                            2. Treatment
                                                                                                                                                                              1. Antiepileptic Drugs
                                                                                                                                                                                1. First-Generation AEDs
                                                                                                                                                                                  1. Phenytoin
                                                                                                                                                                                    1. Mechanism of Action
                                                                                                                                                                                      1. Pharmacokinetics
                                                                                                                                                                                        1. Side Effects
                                                                                                                                                                                          1. Drug Interactions
                                                                                                                                                                                          2. Carbamazepine
                                                                                                                                                                                            1. Mechanism of Action
                                                                                                                                                                                              1. Indications
                                                                                                                                                                                                1. Side Effects
                                                                                                                                                                                                  1. Monitoring
                                                                                                                                                                                                  2. Valproic Acid
                                                                                                                                                                                                    1. Mechanism of Action
                                                                                                                                                                                                      1. Broad Spectrum
                                                                                                                                                                                                        1. Side Effects
                                                                                                                                                                                                          1. Teratogenicity
                                                                                                                                                                                                          2. Phenobarbital
                                                                                                                                                                                                            1. Mechanism of Action
                                                                                                                                                                                                              1. Indications
                                                                                                                                                                                                                1. Side Effects
                                                                                                                                                                                                                2. Primidone
                                                                                                                                                                                                                  1. Mechanism of Action
                                                                                                                                                                                                                    1. Metabolism
                                                                                                                                                                                                                      1. Side Effects
                                                                                                                                                                                                                    2. Second-Generation AEDs
                                                                                                                                                                                                                      1. Lamotrigine
                                                                                                                                                                                                                        1. Mechanism of Action
                                                                                                                                                                                                                          1. Broad Spectrum
                                                                                                                                                                                                                            1. Side Effects
                                                                                                                                                                                                                              1. Drug Interactions
                                                                                                                                                                                                                              2. Levetiracetam
                                                                                                                                                                                                                                1. Mechanism of Action
                                                                                                                                                                                                                                  1. Pharmacokinetics
                                                                                                                                                                                                                                    1. Side Effects
                                                                                                                                                                                                                                      1. Psychiatric Effects
                                                                                                                                                                                                                                      2. Oxcarbazepine
                                                                                                                                                                                                                                        1. Mechanism of Action
                                                                                                                                                                                                                                          1. Comparison with Carbamazepine
                                                                                                                                                                                                                                            1. Side Effects
                                                                                                                                                                                                                                            2. Topiramate
                                                                                                                                                                                                                                              1. Mechanism of Action
                                                                                                                                                                                                                                                1. Multiple Indications
                                                                                                                                                                                                                                                  1. Side Effects
                                                                                                                                                                                                                                                    1. Cognitive Effects
                                                                                                                                                                                                                                                    2. Gabapentin
                                                                                                                                                                                                                                                      1. Mechanism of Action
                                                                                                                                                                                                                                                        1. Pharmacokinetics
                                                                                                                                                                                                                                                          1. Side Effects
                                                                                                                                                                                                                                                          2. Pregabalin
                                                                                                                                                                                                                                                            1. Mechanism of Action
                                                                                                                                                                                                                                                              1. Indications
                                                                                                                                                                                                                                                                1. Side Effects
                                                                                                                                                                                                                                                              2. Third-Generation AEDs
                                                                                                                                                                                                                                                                1. Lacosamide
                                                                                                                                                                                                                                                                  1. Mechanism of Action
                                                                                                                                                                                                                                                                    1. Indications
                                                                                                                                                                                                                                                                      1. Side Effects
                                                                                                                                                                                                                                                                      2. Perampanel
                                                                                                                                                                                                                                                                        1. Mechanism of Action
                                                                                                                                                                                                                                                                          1. Side Effects
                                                                                                                                                                                                                                                                            1. Psychiatric Effects
                                                                                                                                                                                                                                                                            2. Brivaracetam
                                                                                                                                                                                                                                                                              1. Mechanism of Action
                                                                                                                                                                                                                                                                                1. Comparison with Levetiracetam
                                                                                                                                                                                                                                                                                2. Eslicarbazepine
                                                                                                                                                                                                                                                                                  1. Mechanism of Action
                                                                                                                                                                                                                                                                                    1. Indications
                                                                                                                                                                                                                                                                                3. Drug Selection Principles
                                                                                                                                                                                                                                                                                  1. Seizure Type Considerations
                                                                                                                                                                                                                                                                                    1. Patient Factors
                                                                                                                                                                                                                                                                                      1. Side Effect Profiles
                                                                                                                                                                                                                                                                                        1. Drug Interactions
                                                                                                                                                                                                                                                                                          1. Cost Considerations
                                                                                                                                                                                                                                                                                          2. Therapeutic Drug Monitoring
                                                                                                                                                                                                                                                                                            1. Indications for Monitoring
                                                                                                                                                                                                                                                                                              1. Target Levels
                                                                                                                                                                                                                                                                                                1. Timing of Samples
                                                                                                                                                                                                                                                                                                2. Non-Pharmacological Therapies
                                                                                                                                                                                                                                                                                                  1. Ketogenic Diet
                                                                                                                                                                                                                                                                                                    1. Mechanism of Action
                                                                                                                                                                                                                                                                                                      1. Indications
                                                                                                                                                                                                                                                                                                        1. Implementation
                                                                                                                                                                                                                                                                                                          1. Side Effects
                                                                                                                                                                                                                                                                                                          2. Modified Atkins Diet
                                                                                                                                                                                                                                                                                                            1. Vagus Nerve Stimulation
                                                                                                                                                                                                                                                                                                              1. Mechanism of Action
                                                                                                                                                                                                                                                                                                                1. Implantation Procedure
                                                                                                                                                                                                                                                                                                                  1. Programming
                                                                                                                                                                                                                                                                                                                    1. Side Effects
                                                                                                                                                                                                                                                                                                                    2. Responsive Neurostimulation
                                                                                                                                                                                                                                                                                                                      1. Patient Selection
                                                                                                                                                                                                                                                                                                                        1. Implantation
                                                                                                                                                                                                                                                                                                                          1. Programming
                                                                                                                                                                                                                                                                                                                          2. Deep Brain Stimulation
                                                                                                                                                                                                                                                                                                                            1. Targets
                                                                                                                                                                                                                                                                                                                              1. Patient Selection
                                                                                                                                                                                                                                                                                                                            2. Epilepsy Surgery
                                                                                                                                                                                                                                                                                                                              1. Presurgical Evaluation
                                                                                                                                                                                                                                                                                                                                1. Seizure Localization
                                                                                                                                                                                                                                                                                                                                  1. Functional Mapping
                                                                                                                                                                                                                                                                                                                                    1. Risk Assessment
                                                                                                                                                                                                                                                                                                                                    2. Surgical Procedures
                                                                                                                                                                                                                                                                                                                                      1. Temporal Lobectomy
                                                                                                                                                                                                                                                                                                                                        1. Extratemporal Resections
                                                                                                                                                                                                                                                                                                                                          1. Hemispherectomy
                                                                                                                                                                                                                                                                                                                                            1. Corpus Callosotomy
                                                                                                                                                                                                                                                                                                                                              1. Multiple Subpial Transections
                                                                                                                                                                                                                                                                                                                                              2. Outcomes
                                                                                                                                                                                                                                                                                                                                                1. Seizure Freedom Rates
                                                                                                                                                                                                                                                                                                                                                  1. Complications
                                                                                                                                                                                                                                                                                                                                                    1. Quality of Life
                                                                                                                                                                                                                                                                                                                                                2. Status Epilepticus
                                                                                                                                                                                                                                                                                                                                                  1. Definition
                                                                                                                                                                                                                                                                                                                                                    1. Convulsive Status Epilepticus
                                                                                                                                                                                                                                                                                                                                                      1. Non-Convulsive Status Epilepticus
                                                                                                                                                                                                                                                                                                                                                        1. Time Criteria
                                                                                                                                                                                                                                                                                                                                                        2. Classification
                                                                                                                                                                                                                                                                                                                                                          1. Generalized Convulsive SE
                                                                                                                                                                                                                                                                                                                                                            1. Focal SE
                                                                                                                                                                                                                                                                                                                                                              1. Absence SE
                                                                                                                                                                                                                                                                                                                                                                1. Myoclonic SE
                                                                                                                                                                                                                                                                                                                                                                2. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                  1. Failure of Seizure Termination
                                                                                                                                                                                                                                                                                                                                                                    1. Failure of Seizure Initiation Prevention
                                                                                                                                                                                                                                                                                                                                                                      1. Neuronal Injury Mechanisms
                                                                                                                                                                                                                                                                                                                                                                      2. Clinical Presentation
                                                                                                                                                                                                                                                                                                                                                                        1. Convulsive SE
                                                                                                                                                                                                                                                                                                                                                                          1. Non-Convulsive SE
                                                                                                                                                                                                                                                                                                                                                                            1. Subtle SE
                                                                                                                                                                                                                                                                                                                                                                            2. Management
                                                                                                                                                                                                                                                                                                                                                                              1. Initial Stabilization
                                                                                                                                                                                                                                                                                                                                                                                1. Airway Management
                                                                                                                                                                                                                                                                                                                                                                                  1. IV Access
                                                                                                                                                                                                                                                                                                                                                                                    1. Glucose and Thiamine
                                                                                                                                                                                                                                                                                                                                                                                    2. First-Line Treatment
                                                                                                                                                                                                                                                                                                                                                                                      1. Benzodiazepines
                                                                                                                                                                                                                                                                                                                                                                                        1. Lorazepam
                                                                                                                                                                                                                                                                                                                                                                                          1. Diazepam
                                                                                                                                                                                                                                                                                                                                                                                            1. Midazolam
                                                                                                                                                                                                                                                                                                                                                                                          2. Second-Line Treatment
                                                                                                                                                                                                                                                                                                                                                                                            1. Phenytoin
                                                                                                                                                                                                                                                                                                                                                                                              1. Fosphenytoin
                                                                                                                                                                                                                                                                                                                                                                                                1. Valproic Acid
                                                                                                                                                                                                                                                                                                                                                                                                  1. Levetiracetam
                                                                                                                                                                                                                                                                                                                                                                                                  2. Third-Line Treatment
                                                                                                                                                                                                                                                                                                                                                                                                    1. Anesthetic Agents
                                                                                                                                                                                                                                                                                                                                                                                                      1. Propofol
                                                                                                                                                                                                                                                                                                                                                                                                        1. Midazolam
                                                                                                                                                                                                                                                                                                                                                                                                          1. Pentobarbital
                                                                                                                                                                                                                                                                                                                                                                                                        2. Refractory SE
                                                                                                                                                                                                                                                                                                                                                                                                          1. Super-Refractory SE
                                                                                                                                                                                                                                                                                                                                                                                                            1. Novel Therapies
                                                                                                                                                                                                                                                                                                                                                                                                        3. Special Populations
                                                                                                                                                                                                                                                                                                                                                                                                          1. Pediatric Epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                            1. Age-Specific Syndromes
                                                                                                                                                                                                                                                                                                                                                                                                              1. Developmental Considerations
                                                                                                                                                                                                                                                                                                                                                                                                                1. Drug Dosing
                                                                                                                                                                                                                                                                                                                                                                                                                2. Epilepsy in Women
                                                                                                                                                                                                                                                                                                                                                                                                                  1. Hormonal Effects
                                                                                                                                                                                                                                                                                                                                                                                                                    1. Contraception
                                                                                                                                                                                                                                                                                                                                                                                                                      1. Pregnancy Management
                                                                                                                                                                                                                                                                                                                                                                                                                        1. Teratogenicity
                                                                                                                                                                                                                                                                                                                                                                                                                        2. Elderly Epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                          1. Etiology Differences
                                                                                                                                                                                                                                                                                                                                                                                                                            1. Drug Considerations
                                                                                                                                                                                                                                                                                                                                                                                                                              1. Comorbidities
                                                                                                                                                                                                                                                                                                                                                                                                                            2. Psychosocial Aspects
                                                                                                                                                                                                                                                                                                                                                                                                                              1. Quality of Life
                                                                                                                                                                                                                                                                                                                                                                                                                                1. Driving Restrictions
                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Employment Issues
                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Stigma and Discrimination
                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Support Groups
                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Headache Disorders
                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Primary Headaches
                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Migraine
                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Epidemiology
                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Prevalence by Age and Sex
                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Genetic Factors
                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Environmental Triggers
                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Trigeminovascular System
                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Cortical Spreading Depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Neurotransmitter Systems
                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Genetic Mechanisms
                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Migraine without Aura
                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Diagnostic Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Pain Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Associated Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Migraine with Aura
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Aura Types
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Visual Aura
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Sensory Aura
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Speech/Language Aura
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Motor Aura
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Chronic Migraine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Transformation Process
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Risk Factors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Complications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Status Migrainosus
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Persistent Aura
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Migrainous Infarction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Triggers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Dietary Triggers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Hormonal Triggers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Environmental Triggers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Stress and Sleep
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Clinical Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Headache Diary
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Red Flags
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Neuroimaging Indications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Acute Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Simple Analgesics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. NSAIDs
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Triptans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Mechanism of Action
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Individual Triptans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Contraindications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Side Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Ergot Alkaloids
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Anti-Emetics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Combination Medications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Preventive Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Indications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Beta-Blockers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Anticonvulsants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Antidepressants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Calcium Channel Blockers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. CGRP Antagonists
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Botulinum Toxin
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Monoclonal Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Non-Pharmacological Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Lifestyle Modifications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Trigger Avoidance
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Stress Management
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Biofeedback
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Acupuncture
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Tension-Type Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Epidemiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Peripheral Mechanisms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Central Sensitization
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Episodic TTH
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Chronic TTH
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Pain Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Clinical Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Differential Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Acute Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Preventive Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Non-Pharmacological Approaches
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Cluster Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Epidemiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Male Predominance
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Age of Onset
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Circadian Patterns
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Hypothalamic Involvement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Trigeminal-Autonomic Reflex
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Circadian Dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Pain Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Autonomic Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Cluster Periods
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Circadian Timing
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Clinical Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Differential Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Acute Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. High-Flow Oxygen
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Triptans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Octreotide
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Preventive Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Verapamil
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Lithium
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Topiramate
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Corticosteroids
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Surgical Options
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Deep Brain Stimulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Gamma Knife Surgery
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3. Other Primary Headaches
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Trigeminal Autonomic Cephalalgias
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Paroxysmal Hemicrania
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. SUNCT/SUNA
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Hemicrania Continua
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Primary Stabbing Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Primary Cough Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Primary Exercise Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Primary Headache Associated with Sexual Activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Primary Thunderclap Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Secondary Headaches
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Headache Attributed to Head/Neck Trauma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Post-Traumatic Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Whiplash-Associated Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Headache Attributed to Cranial/Cervical Vascular Disorder
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Subarachnoid Hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Intracerebral Hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Ischemic Stroke
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Arterial Dissection
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Giant Cell Arteritis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Headache Attributed to Non-Vascular Intracranial Disorder
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Increased Intracranial Pressure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Decreased Intracranial Pressure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Brain Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Meningitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Encephalitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Headache Attributed to Substance Use/Withdrawal
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Medication Overuse Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Caffeine Withdrawal
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Headache Attributed to Infection
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Systemic Infections
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Intracranial Infections
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Headache Attributed to Disorder of Homeostasis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Hypoxia/Hypercapnia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Dialysis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Arterial Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Hypothyroidism
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Facial Pain Syndromes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Trigeminal Neuralgia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Epidemiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Vascular Compression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Demyelination
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Central Mechanisms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Classical TN
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Secondary TN
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Pain Characteristics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Trigger Zones
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Clinical Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Neuroimaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Differential Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Medical Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Carbamazepine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Oxcarbazepine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Baclofen
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Gabapentin
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Pregabalin
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Surgical Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Microvascular Decompression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Gamma Knife Radiosurgery
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Balloon Compression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Glycerol Rhizolysis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Radiofrequency Thermocoagulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Glossopharyngeal Neuralgia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Atypical Facial Pain
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Post-Herpetic Neuralgia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Prevention
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Neuromuscular Junction Disorders
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Myasthenia Gravis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Epidemiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Bimodal Age Distribution
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Sex Differences
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Associated Conditions
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Autoimmune Mechanisms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Acetylcholine Receptor Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. MuSK Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. LRP4 Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Complement Activation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Thymic Abnormalities
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Muscle Weakness Patterns
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Ocular Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Bulbar Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Limb Weakness
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Respiratory Weakness
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Fatigability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Fluctuating Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Myasthenic Crisis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Classification
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Ocular Myasthenia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Generalized Myasthenia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Severity Classifications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Clinical Assessment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Edrophonium Test
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Ice Pack Test
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Rest Test
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Antibody Testing
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. AChR Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. MuSK Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. LRP4 Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Electrophysiological Testing
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Repetitive Nerve Stimulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Single Fiber EMG
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Jitter Analysis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Imaging Studies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Chest CT/MRI
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Thymic Evaluation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Symptomatic Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Acetylcholinesterase Inhibitors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Pyridostigmine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Neostigmine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Dosing and Side Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Immunosuppressive Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Corticosteroids
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Prednisone
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Initiation and Tapering
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Side Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Steroid-Sparing Agents
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Azathioprine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Mycophenolate Mofetil
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Methotrexate
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Cyclosporine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Tacrolimus
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Rapid Immunomodulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Plasma Exchange
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Indications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Procedure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Complications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Intravenous Immunoglobulin
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Mechanism
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Dosing
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Side Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Surgical Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Thymectomy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Indications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Surgical Approaches
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Outcomes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Complications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Emerging Therapies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Rituximab
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Eculizumab
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Complement Inhibitors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Myasthenic Crisis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Precipitating Factors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Management
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Respiratory Support
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Immunomodulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Supportive Care
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Special Considerations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Pregnancy and MG
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Neonatal Myasthenia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Drug Interactions
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Anesthesia Considerations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Lambert-Eaton Myasthenic Syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Voltage-Gated Calcium Channel Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Presynaptic Dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Paraneoplastic Associations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Proximal Weakness
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Post-Exercise Facilitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Autonomic Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Associated Malignancies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Electrophysiological Testing
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Antibody Testing
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Cancer Screening
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Symptomatic Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Immunosuppression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Cancer Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Congenital Myasthenic Syndromes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Genetic Basis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Botulism
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Central Nervous System Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Epidemiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Incidence by Age
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Primary vs Metastatic
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Geographic Variations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Risk Factors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Genetic Syndromes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Environmental Factors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Radiation Exposure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Immunosuppression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Classification
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. WHO Classification System
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Grading System
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Molecular Markers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Genetic Alterations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Primary Brain Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Gliomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Astrocytomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Pilocytic Astrocytoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Diffuse Astrocytoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Anaplastic Astrocytoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Glioblastoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. IDH-Wildtype
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. IDH-Mutant
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Molecular Subtypes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Oligodendrogliomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Oligodendroglioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Anaplastic Oligodendroglioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. 1p/19q Codeletion
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Ependymomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Subependymoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Myxopapillary Ependymoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Ependymoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Anaplastic Ependymoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Mixed Gliomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Oligoastrocytoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3. Meningiomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. WHO Grade I
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. WHO Grade II
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. WHO Grade III
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Location-Based Classification
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Molecular Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Pituitary Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Adenomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Functioning Adenomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Non-Functioning Adenomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Craniopharyngioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Other Sellar Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Primary CNS Lymphoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Immunocompetent Patients
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Immunocompromised Patients
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Molecular Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Medulloepithelioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Pediatric Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Molecular Subgroups
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Risk Stratification
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Schwannomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Vestibular Schwannoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Other Cranial Nerve Schwannomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Spinal Schwannomas
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Other Primary Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Choroid Plexus Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Pineal Region Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Embryonal Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Metastatic Brain Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Common Primary Sources
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Lung Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Breast Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Melanoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Renal Cell Carcinoma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Colorectal Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Metastatic Cascade
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Blood-Brain Barrier
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Tumor Microenvironment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Clinical Patterns
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Single vs Multiple Metastases
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Location Preferences
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Leptomeningeal Disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Clinical Presentation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Mass Effect Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Headache
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Nausea and Vomiting
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Altered Mental Status
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Papilledema
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Focal Neurological Deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Motor Weakness
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Sensory Loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Language Disorders
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Visual Field Defects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Seizures
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Focal Seizures
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Generalized Seizures
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Status Epilepticus
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Cognitive and Behavioral Changes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Personality Changes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Executive Dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Location-Specific Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Frontal Lobe Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Temporal Lobe Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Parietal Lobe Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Occipital Lobe Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Brainstem Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Cerebellar Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Diagnostic Evaluation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Neuroimaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Computed Tomography
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Non-Contrast CT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Contrast-Enhanced CT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Magnetic Resonance Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. T1-Weighted Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. T2-Weighted Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. FLAIR Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Diffusion-Weighted Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Perfusion Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Spectroscopy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Functional MRI
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Advanced Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. PET Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. SPECT Imaging
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. DTI
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Tissue Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Stereotactic Biopsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Open Biopsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Intraoperative Consultation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Molecular Testing
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. IDH Mutations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. 1p/19q Codeletion
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. MGMT Methylation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. EGFR Amplification
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Laboratory Studies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Tumor Markers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. CSF Analysis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Genetic Testing
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Treatment Modalities
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Surgical Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Gross Total Resection
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Subtotal Resection
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Biopsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Intraoperative Monitoring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Awake Craniotomy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Stereotactic Surgery
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Complications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2. Radiation Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. External Beam Radiation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Conventional RT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Intensity-Modulated RT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Stereotactic RT
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Stereotactic Radiosurgery
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Gamma Knife
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Linear Accelerator
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. CyberKnife
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Brachytherapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Proton Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Side Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Acute Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Late Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Radiation Necrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Chemotherapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Alkylating Agents
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Temozolomide
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Carmustine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Lomustine
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Antimetabolites
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Methotrexate
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. 5-Fluorouracil
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Targeted Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Bevacizumab
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Erlotinib
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Imatinib
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Immunotherapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Checkpoint Inhibitors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. CAR-T Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Vaccines
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Drug Delivery
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Blood-Brain Barrier
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Convection-Enhanced Delivery
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Intrathecal Administration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Supportive Care
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Corticosteroids
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Dexamethasone
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Indications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Side Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Antiepileptic Drugs
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Prophylactic Use
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Treatment of Seizures
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Anticoagulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Thromboembolism Risk
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Bleeding Risk
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Rehabilitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Physical Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Occupational Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Speech Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Cognitive Rehabilitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Prognosis and Outcomes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Prognostic Factors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Tumor Type and Grade
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Molecular Markers
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Age
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Performance Status
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Extent of Resection
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Survival Statistics
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Overall Survival
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Progression-Free Survival
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Quality of Life Measures
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Long-Term Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Cognitive Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Neurological Deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Secondary Malignancies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Special Considerations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Pediatric Brain Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Age-Specific Considerations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Developmental Impact
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Treatment Modifications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Elderly Patients
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Comorbidities
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Treatment Tolerance
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Goals of Care
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Pregnancy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Diagnostic Considerations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Treatment Modifications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Fetal Considerations

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Previous

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        4. Demyelinating and Inflammatory Disorders

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Go to top

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Back to Start

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Fundamentals of Clinical Neuroscience