Stroke and Neurological Disorders

  1. Demyelinating and Inflammatory Disorders
    1. Multiple Sclerosis
      1. Epidemiology
        1. Global Distribution
          1. Latitude Effect
            1. Age and Sex Distribution
              1. Risk Factors
                1. Genetic Factors
                  1. Environmental Factors
                    1. Infectious Agents
                      1. Vitamin D Deficiency
                    2. Pathophysiology
                      1. Autoimmune Mechanisms
                        1. T-Cell Activation
                          1. B-Cell Involvement
                            1. Molecular Mimicry
                            2. Demyelination Process
                              1. Oligodendrocyte Damage
                                1. Myelin Breakdown
                                  1. Inflammatory Infiltration
                                  2. Axonal Damage
                                    1. Primary Axonal Loss
                                      1. Secondary Degeneration
                                        1. Neurodegeneration
                                        2. Blood-Brain Barrier Disruption
                                          1. Inflammatory Mediators
                                            1. Gadolinium Enhancement
                                          2. Clinical Course Types
                                            1. Relapsing-Remitting MS
                                              1. Attack Patterns
                                                1. Recovery Phases
                                                  1. Disability Progression
                                                  2. Secondary Progressive MS
                                                    1. Transition from RRMS
                                                      1. Progressive Disability
                                                        1. Inflammatory Activity
                                                        2. Primary Progressive MS
                                                          1. Gradual Onset
                                                            1. Steady Progression
                                                              1. Spinal Cord Involvement
                                                              2. Progressive-Relapsing MS
                                                                1. Rare Subtype
                                                                  1. Progressive Course with Relapses
                                                                2. Clinical Manifestations
                                                                  1. Motor Symptoms
                                                                    1. Weakness
                                                                      1. Spasticity
                                                                        1. Gait Disorders
                                                                          1. Tremor
                                                                          2. Sensory Symptoms
                                                                            1. Numbness
                                                                              1. Tingling
                                                                                1. Pain
                                                                                  1. Lhermitte's Sign
                                                                                  2. Visual Symptoms
                                                                                    1. Optic Neuritis
                                                                                      1. Diplopia
                                                                                        1. Nystagmus
                                                                                          1. Visual Field Defects
                                                                                          2. Brainstem Symptoms
                                                                                            1. Vertigo
                                                                                              1. Dysarthria
                                                                                                1. Dysphagia
                                                                                                  1. Facial Weakness
                                                                                                  2. Cerebellar Symptoms
                                                                                                    1. Ataxia
                                                                                                      1. Intention Tremor
                                                                                                        1. Dysmetria
                                                                                                          1. Balance Problems
                                                                                                          2. Cognitive Symptoms
                                                                                                            1. Memory Impairment
                                                                                                              1. Executive Dysfunction
                                                                                                                1. Processing Speed
                                                                                                                  1. Attention Deficits
                                                                                                                  2. Neuropsychiatric Symptoms
                                                                                                                    1. Depression
                                                                                                                      1. Anxiety
                                                                                                                        1. Mood Swings
                                                                                                                          1. Pseudobulbar Affect
                                                                                                                          2. Autonomic Symptoms
                                                                                                                            1. Bladder Dysfunction
                                                                                                                              1. Bowel Dysfunction
                                                                                                                                1. Sexual Dysfunction
                                                                                                                                  1. Temperature Regulation
                                                                                                                                  2. Fatigue
                                                                                                                                    1. Primary Fatigue
                                                                                                                                      1. Secondary Fatigue
                                                                                                                                        1. Heat Sensitivity
                                                                                                                                      2. Diagnostic Approach
                                                                                                                                        1. McDonald Criteria
                                                                                                                                          1. Dissemination in Space
                                                                                                                                            1. Dissemination in Time
                                                                                                                                              1. Clinical Presentation
                                                                                                                                                1. Paraclinical Evidence
                                                                                                                                                2. Magnetic Resonance Imaging
                                                                                                                                                  1. T2-Weighted Lesions
                                                                                                                                                    1. Gadolinium Enhancement
                                                                                                                                                      1. T1 Hypointense Lesions
                                                                                                                                                        1. Brain and Spinal Cord
                                                                                                                                                        2. Cerebrospinal Fluid Analysis
                                                                                                                                                          1. Oligoclonal Bands
                                                                                                                                                            1. IgG Index
                                                                                                                                                              1. Cell Count
                                                                                                                                                                1. Protein Levels
                                                                                                                                                                2. Evoked Potentials
                                                                                                                                                                  1. Visual Evoked Potentials
                                                                                                                                                                    1. Brainstem Auditory Evoked Potentials
                                                                                                                                                                      1. Somatosensory Evoked Potentials
                                                                                                                                                                      2. Differential Diagnosis
                                                                                                                                                                        1. Neuromyelitis Optica
                                                                                                                                                                          1. Acute Disseminated Encephalomyelitis
                                                                                                                                                                            1. CNS Vasculitis
                                                                                                                                                                              1. Sarcoidosis
                                                                                                                                                                            2. Treatment
                                                                                                                                                                              1. Acute Relapse Treatment
                                                                                                                                                                                1. High-Dose Corticosteroids
                                                                                                                                                                                  1. Methylprednisolone
                                                                                                                                                                                    1. Oral Prednisone
                                                                                                                                                                                    2. Plasma Exchange
                                                                                                                                                                                      1. Indications
                                                                                                                                                                                        1. Procedure
                                                                                                                                                                                          1. Complications
                                                                                                                                                                                        2. Disease-Modifying Therapies
                                                                                                                                                                                          1. Injectable Therapies
                                                                                                                                                                                            1. Interferon Beta
                                                                                                                                                                                              1. Interferon Beta-1a
                                                                                                                                                                                                1. Interferon Beta-1b
                                                                                                                                                                                                  1. Mechanism of Action
                                                                                                                                                                                                    1. Side Effects
                                                                                                                                                                                                    2. Glatiramer Acetate
                                                                                                                                                                                                      1. Mechanism of Action
                                                                                                                                                                                                        1. Administration
                                                                                                                                                                                                          1. Side Effects
                                                                                                                                                                                                        2. Oral Therapies
                                                                                                                                                                                                          1. Fingolimod
                                                                                                                                                                                                            1. Mechanism of Action
                                                                                                                                                                                                              1. Monitoring Requirements
                                                                                                                                                                                                                1. Side Effects
                                                                                                                                                                                                                2. Dimethyl Fumarate
                                                                                                                                                                                                                  1. Mechanism of Action
                                                                                                                                                                                                                    1. Side Effects
                                                                                                                                                                                                                      1. Monitoring
                                                                                                                                                                                                                      2. Teriflunomide
                                                                                                                                                                                                                        1. Mechanism of Action
                                                                                                                                                                                                                          1. Side Effects
                                                                                                                                                                                                                            1. Contraindications
                                                                                                                                                                                                                            2. Cladribine
                                                                                                                                                                                                                              1. Mechanism of Action
                                                                                                                                                                                                                                1. Administration Schedule
                                                                                                                                                                                                                                  1. Monitoring
                                                                                                                                                                                                                                2. Infusion Therapies
                                                                                                                                                                                                                                  1. Natalizumab
                                                                                                                                                                                                                                    1. Mechanism of Action
                                                                                                                                                                                                                                      1. PML Risk
                                                                                                                                                                                                                                        1. Monitoring Requirements
                                                                                                                                                                                                                                        2. Alemtuzumab
                                                                                                                                                                                                                                          1. Mechanism of Action
                                                                                                                                                                                                                                            1. Administration Protocol
                                                                                                                                                                                                                                              1. Side Effects
                                                                                                                                                                                                                                              2. Ocrelizumab
                                                                                                                                                                                                                                                1. Mechanism of Action
                                                                                                                                                                                                                                                  1. Indications
                                                                                                                                                                                                                                                    1. Side Effects
                                                                                                                                                                                                                                                    2. Rituximab
                                                                                                                                                                                                                                                      1. Off-Label Use
                                                                                                                                                                                                                                                        1. Mechanism of Action
                                                                                                                                                                                                                                                    3. Symptomatic Management
                                                                                                                                                                                                                                                      1. Spasticity
                                                                                                                                                                                                                                                        1. Baclofen
                                                                                                                                                                                                                                                          1. Tizanidine
                                                                                                                                                                                                                                                            1. Botulinum Toxin
                                                                                                                                                                                                                                                              1. Intrathecal Baclofen
                                                                                                                                                                                                                                                              2. Fatigue
                                                                                                                                                                                                                                                                1. Amantadine
                                                                                                                                                                                                                                                                  1. Modafinil
                                                                                                                                                                                                                                                                    1. Energy Conservation
                                                                                                                                                                                                                                                                    2. Bladder Dysfunction
                                                                                                                                                                                                                                                                      1. Anticholinergics
                                                                                                                                                                                                                                                                        1. Intermittent Catheterization
                                                                                                                                                                                                                                                                          1. Botulinum Toxin
                                                                                                                                                                                                                                                                          2. Pain
                                                                                                                                                                                                                                                                            1. Neuropathic Pain Medications
                                                                                                                                                                                                                                                                              1. Anticonvulsants
                                                                                                                                                                                                                                                                                1. Antidepressants
                                                                                                                                                                                                                                                                                2. Depression
                                                                                                                                                                                                                                                                                  1. Antidepressants
                                                                                                                                                                                                                                                                                    1. Counseling
                                                                                                                                                                                                                                                                                      1. Support Groups
                                                                                                                                                                                                                                                                                  2. Rehabilitation
                                                                                                                                                                                                                                                                                    1. Physical Therapy
                                                                                                                                                                                                                                                                                      1. Mobility Training
                                                                                                                                                                                                                                                                                        1. Strength Training
                                                                                                                                                                                                                                                                                          1. Balance Training
                                                                                                                                                                                                                                                                                          2. Occupational Therapy
                                                                                                                                                                                                                                                                                            1. Activities of Daily Living
                                                                                                                                                                                                                                                                                              1. Adaptive Equipment
                                                                                                                                                                                                                                                                                                1. Energy Conservation
                                                                                                                                                                                                                                                                                                2. Speech Therapy
                                                                                                                                                                                                                                                                                                  1. Dysarthria Treatment
                                                                                                                                                                                                                                                                                                    1. Swallowing Assessment
                                                                                                                                                                                                                                                                                                    2. Cognitive Rehabilitation
                                                                                                                                                                                                                                                                                                      1. Memory Strategies
                                                                                                                                                                                                                                                                                                        1. Attention Training
                                                                                                                                                                                                                                                                                                      2. Prognosis
                                                                                                                                                                                                                                                                                                        1. Prognostic Factors
                                                                                                                                                                                                                                                                                                          1. Age at Onset
                                                                                                                                                                                                                                                                                                            1. Initial Symptoms
                                                                                                                                                                                                                                                                                                              1. MRI Findings
                                                                                                                                                                                                                                                                                                                1. Response to Treatment
                                                                                                                                                                                                                                                                                                                2. Disability Measures
                                                                                                                                                                                                                                                                                                                  1. Expanded Disability Status Scale
                                                                                                                                                                                                                                                                                                                    1. Multiple Sclerosis Functional Composite
                                                                                                                                                                                                                                                                                                                    2. Long-Term Outcomes
                                                                                                                                                                                                                                                                                                                      1. Disability Progression
                                                                                                                                                                                                                                                                                                                        1. Quality of Life
                                                                                                                                                                                                                                                                                                                          1. Life Expectancy
                                                                                                                                                                                                                                                                                                                      2. Neuromyelitis Optica Spectrum Disorders
                                                                                                                                                                                                                                                                                                                        1. Pathophysiology
                                                                                                                                                                                                                                                                                                                          1. Aquaporin-4 Antibodies
                                                                                                                                                                                                                                                                                                                            1. Complement Activation
                                                                                                                                                                                                                                                                                                                              1. Astrocyte Damage
                                                                                                                                                                                                                                                                                                                              2. Clinical Features
                                                                                                                                                                                                                                                                                                                                1. Optic Neuritis
                                                                                                                                                                                                                                                                                                                                  1. Transverse Myelitis
                                                                                                                                                                                                                                                                                                                                    1. Brainstem Syndromes
                                                                                                                                                                                                                                                                                                                                      1. Cerebral Syndromes
                                                                                                                                                                                                                                                                                                                                      2. Diagnostic Criteria
                                                                                                                                                                                                                                                                                                                                        1. Core Clinical Characteristics
                                                                                                                                                                                                                                                                                                                                          1. MRI Features
                                                                                                                                                                                                                                                                                                                                            1. AQP4-IgG Seropositivity
                                                                                                                                                                                                                                                                                                                                            2. Treatment
                                                                                                                                                                                                                                                                                                                                              1. Acute Treatment
                                                                                                                                                                                                                                                                                                                                                1. Immunosuppressive Therapy
                                                                                                                                                                                                                                                                                                                                                  1. Rituximab
                                                                                                                                                                                                                                                                                                                                                    1. Emerging Therapies
                                                                                                                                                                                                                                                                                                                                                  2. Acute Disseminated Encephalomyelitis
                                                                                                                                                                                                                                                                                                                                                    1. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                      1. Post-Infectious Demyelination
                                                                                                                                                                                                                                                                                                                                                        1. Molecular Mimicry
                                                                                                                                                                                                                                                                                                                                                        2. Clinical Features
                                                                                                                                                                                                                                                                                                                                                          1. Acute Onset
                                                                                                                                                                                                                                                                                                                                                            1. Multifocal Symptoms
                                                                                                                                                                                                                                                                                                                                                              1. Encephalopathy
                                                                                                                                                                                                                                                                                                                                                              2. Diagnostic Approach
                                                                                                                                                                                                                                                                                                                                                                1. MRI Findings
                                                                                                                                                                                                                                                                                                                                                                  1. CSF Analysis
                                                                                                                                                                                                                                                                                                                                                                    1. Clinical Course
                                                                                                                                                                                                                                                                                                                                                                    2. Treatment
                                                                                                                                                                                                                                                                                                                                                                      1. Corticosteroids
                                                                                                                                                                                                                                                                                                                                                                        1. IVIG
                                                                                                                                                                                                                                                                                                                                                                          1. Plasma Exchange
                                                                                                                                                                                                                                                                                                                                                                        2. Guillain-Barré Syndrome
                                                                                                                                                                                                                                                                                                                                                                          1. Epidemiology
                                                                                                                                                                                                                                                                                                                                                                            1. Incidence Rates
                                                                                                                                                                                                                                                                                                                                                                              1. Age Distribution
                                                                                                                                                                                                                                                                                                                                                                                1. Seasonal Variation
                                                                                                                                                                                                                                                                                                                                                                                  1. Triggering Factors
                                                                                                                                                                                                                                                                                                                                                                                    1. Infections
                                                                                                                                                                                                                                                                                                                                                                                      1. Vaccinations
                                                                                                                                                                                                                                                                                                                                                                                        1. Surgery
                                                                                                                                                                                                                                                                                                                                                                                      2. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                        1. Autoimmune Mechanisms
                                                                                                                                                                                                                                                                                                                                                                                          1. Molecular Mimicry
                                                                                                                                                                                                                                                                                                                                                                                            1. Cross-Reactive Antibodies
                                                                                                                                                                                                                                                                                                                                                                                            2. Demyelinating Variants
                                                                                                                                                                                                                                                                                                                                                                                              1. Acute Inflammatory Demyelinating Polyneuropathy
                                                                                                                                                                                                                                                                                                                                                                                                1. Chronic Inflammatory Demyelinating Polyneuropathy
                                                                                                                                                                                                                                                                                                                                                                                                2. Axonal Variants
                                                                                                                                                                                                                                                                                                                                                                                                  1. Acute Motor Axonal Neuropathy
                                                                                                                                                                                                                                                                                                                                                                                                    1. Acute Motor and Sensory Axonal Neuropathy
                                                                                                                                                                                                                                                                                                                                                                                                  2. Clinical Presentation
                                                                                                                                                                                                                                                                                                                                                                                                    1. Ascending Paralysis
                                                                                                                                                                                                                                                                                                                                                                                                      1. Distal to Proximal Progression
                                                                                                                                                                                                                                                                                                                                                                                                        1. Symmetric Weakness
                                                                                                                                                                                                                                                                                                                                                                                                          1. Areflexia
                                                                                                                                                                                                                                                                                                                                                                                                          2. Sensory Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                            1. Paresthesias
                                                                                                                                                                                                                                                                                                                                                                                                              1. Pain
                                                                                                                                                                                                                                                                                                                                                                                                                1. Sensory Loss
                                                                                                                                                                                                                                                                                                                                                                                                                2. Cranial Nerve Involvement
                                                                                                                                                                                                                                                                                                                                                                                                                  1. Facial Weakness
                                                                                                                                                                                                                                                                                                                                                                                                                    1. Bulbar Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                      1. Ophthalmoplegia
                                                                                                                                                                                                                                                                                                                                                                                                                      2. Autonomic Dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                        1. Cardiovascular Instability
                                                                                                                                                                                                                                                                                                                                                                                                                          1. Gastrointestinal Dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                            1. Sudomotor Dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                            2. Respiratory Involvement
                                                                                                                                                                                                                                                                                                                                                                                                                              1. Respiratory Muscle Weakness
                                                                                                                                                                                                                                                                                                                                                                                                                                1. Ventilatory Failure
                                                                                                                                                                                                                                                                                                                                                                                                                              2. Diagnostic Approach
                                                                                                                                                                                                                                                                                                                                                                                                                                1. Clinical Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Hughes Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Brighton Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                    2. Nerve Conduction Studies
                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Demyelinating Features
                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Axonal Features
                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Conduction Blocks
                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Cerebrospinal Fluid Analysis
                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Cytoalbuminous Dissociation
                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Protein Elevation
                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Cell Count
                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Antibody Testing
                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Anti-GM1 Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Anti-GQ1b Antibodies
                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Immunomodulatory Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Intravenous Immunoglobulin
                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Mechanism of Action
                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Dosing Regimen
                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Side Effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Plasma Exchange
                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Indications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Procedure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Complications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Comparison of Therapies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3. Supportive Care
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Respiratory Management
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Monitoring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Mechanical Ventilation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Cardiovascular Monitoring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Arrhythmia Detection
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Blood Pressure Management
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2. Pain Management
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Neuropathic Pain
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Musculoskeletal Pain
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Rehabilitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Physical Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Occupational Therapy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                3. Prognosis and Recovery
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Recovery Phases
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Acute Phase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Recovery Phase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Residual Phase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2. Prognostic Factors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Age
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Severity at Nadir
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Axonal Involvement
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Preceding Infection
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Functional Outcomes
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Disability Measures
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Return to Work
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Quality of Life
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2. Complications
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Respiratory Failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Autonomic Dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Thromboembolism
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Infections
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Chronic Inflammatory Demyelinating Polyneuropathy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Chronic Demyelination
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. Inflammatory Infiltration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. Remyelination
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Progressive Weakness
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Sensory Symptoms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1. Areflexia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1. Course Variants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2. Diagnostic Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1. Clinical Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1. Electrophysiological Criteria
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1. CSF Findings
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2. Treatment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1. First-Line Therapies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1. Second-Line Therapies
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1. Maintenance Treatment

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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Go to top

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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  5. Other Major Neurological Disorders