Neural Development

  1. Circuit Maturation and Refinement
    1. Activity-Dependent Development
      1. Spontaneous Activity
        1. Retinal Waves
          1. Spinal Cord Bursts
            1. Cortical Up-States
            2. Experience-Dependent Plasticity
              1. Sensory Experience
                1. Motor Learning
                  1. Social Interaction
                  2. Hebbian Mechanisms
                    1. Coincidence Detection
                      1. LTP and LTD
                        1. Spike-Timing Dependent Plasticity
                      2. Synaptic Pruning
                        1. Developmental Synaptic Elimination
                          1. Neuromuscular Junction
                            1. Climbing Fiber Synapses
                              1. Cortical Synapses
                              2. Pruning Mechanisms
                                1. Activity-Dependent Competition
                                  1. Complement-Mediated Elimination
                                    1. Microglial Phagocytosis
                                    2. Molecular Signals
                                      1. C1q and C3
                                        1. Fractalkine Signaling
                                          1. Purinergic Signaling
                                        2. Myelination
                                          1. Oligodendrocyte Maturation
                                            1. OPC Specification
                                              1. Migration and Proliferation
                                                1. Terminal Differentiation
                                                2. Myelin Formation
                                                  1. Axon Recognition
                                                    1. Wrapping Process
                                                      1. Myelin Compaction
                                                      2. Schwann Cell Development
                                                        1. Neural Crest Origin
                                                          1. Radial Sorting
                                                            1. Myelination Program
                                                            2. Axon-Glia Interactions
                                                              1. Neuregulin Signaling
                                                                1. Electrical Activity Effects
                                                                  1. Metabolic Support
                                                                2. Critical Periods
                                                                  1. Definition and Properties
                                                                    1. Timing Mechanisms
                                                                      1. Opening Triggers
                                                                        1. Closing Mechanisms
                                                                        2. Visual System Plasticity
                                                                          1. Ocular Dominance Columns
                                                                            1. Monocular Deprivation
                                                                              1. Amblyopia
                                                                              2. Auditory System Development
                                                                                1. Tonotopic Mapping
                                                                                  1. Binaural Processing
                                                                                  2. Language Acquisition
                                                                                    1. Phoneme Discrimination
                                                                                      1. Grammar Learning
                                                                                      2. Molecular Brakes
                                                                                        1. Perineuronal Nets
                                                                                          1. Myelin Inhibitors
                                                                                            1. GABA Maturation

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                                                                                        4. Neural Circuit Formation

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                                                                                        6. Regional Neural Development