Neural Development

  1. Neural Circuit Formation
    1. Axon Development
      1. Growth Cone Structure
        1. Central Domain
          1. Peripheral Domain
            1. Lamellipodia
              1. Filopodia
              2. Cytoskeletal Organization
                1. F-actin Networks
                  1. Microtubule Arrays
                2. Axon Elongation
                  1. Growth Cone Advance
                    1. Cytoskeletal Dynamics
                      1. Membrane Addition
                      2. Axon Guidance Mechanisms
                        1. Contact-Mediated Guidance
                          1. Adhesive Interactions
                            1. Repulsive Interactions
                            2. Chemotropic Guidance
                              1. Attractive Cues
                                1. Repulsive Cues
                              2. Guidance Molecules
                                1. Netrins
                                  1. DCC Receptors
                                    1. UNC5 Receptors
                                    2. Semaphorins
                                      1. Plexin Receptors
                                        1. Neuropilin Co-receptors
                                        2. Ephrins
                                          1. Eph Receptors
                                            1. Forward and Reverse Signaling
                                            2. Slits
                                              1. Robo Receptors
                                                1. Commissural Regulation
                                              2. Axon Fasciculation
                                                1. Homophilic Adhesion
                                                  1. Pioneer Axons
                                                    1. Selective Fasciculation
                                                    2. Target Recognition
                                                      1. Molecular Matching
                                                        1. Activity-Dependent Selection
                                                          1. Topographic Mapping
                                                        2. Dendrite Development
                                                          1. Dendrite Initiation
                                                            1. Polarity Establishment
                                                              1. Initial Branching
                                                              2. Dendritic Arborization
                                                                1. Branch Extension
                                                                  1. Branch Stabilization
                                                                    1. Branch Elimination
                                                                    2. Dendritic Spine Formation
                                                                      1. Spine Morphogenesis
                                                                        1. Spine Types
                                                                          1. Stubby Spines
                                                                            1. Mushroom Spines
                                                                              1. Thin Spines
                                                                              2. Spine Dynamics
                                                                              3. Molecular Regulation
                                                                                1. Rho Family GTPases
                                                                                  1. CREB Signaling
                                                                                    1. Calcium Signaling
                                                                                  2. Synaptogenesis
                                                                                    1. Synapse Induction
                                                                                      1. Initial Contact
                                                                                        1. Adhesive Interactions
                                                                                        2. Presynaptic Development
                                                                                          1. Active Zone Assembly
                                                                                            1. Vesicle Clustering
                                                                                              1. Calcium Channel Localization
                                                                                              2. Postsynaptic Development
                                                                                                1. Receptor Clustering
                                                                                                  1. Scaffold Assembly
                                                                                                    1. Postsynaptic Density Formation
                                                                                                    2. Synaptic Adhesion Molecules
                                                                                                      1. Neurexins and Neuroligins
                                                                                                        1. Cadherins
                                                                                                          1. SynCAMs
                                                                                                          2. Trans-Synaptic Signaling
                                                                                                            1. Retrograde Signals
                                                                                                              1. Anterograde Signals
                                                                                                              2. Glial Involvement
                                                                                                                1. Astrocytic Processes
                                                                                                                  1. Synaptogenic Factors
                                                                                                                    1. Synaptic Pruning
                                                                                                                  2. Programmed Cell Death
                                                                                                                    1. Neurotrophic Theory
                                                                                                                      1. Target-Derived Support
                                                                                                                        1. Competition for Survival
                                                                                                                        2. Apoptotic Machinery
                                                                                                                          1. Caspase Cascade
                                                                                                                            1. Bcl-2 Family Proteins
                                                                                                                              1. Mitochondrial Pathway
                                                                                                                              2. Neurotrophic Factors
                                                                                                                                1. Nerve Growth Factor
                                                                                                                                  1. Brain-Derived Neurotrophic Factor
                                                                                                                                    1. Neurotrophin-3
                                                                                                                                      1. Neurotrophin-4/5
                                                                                                                                      2. Trk Receptor Signaling
                                                                                                                                        1. TrkA Signaling
                                                                                                                                          1. TrkB Signaling
                                                                                                                                            1. TrkC Signaling
                                                                                                                                            2. Developmental Timing
                                                                                                                                              1. Critical Periods
                                                                                                                                                1. Regional Differences

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                                                                                                                                            3. Cellular Mechanisms of Neural Development

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                                                                                                                                            5. Circuit Maturation and Refinement