Neural Development

  1. Cellular Mechanisms of Neural Development
    1. Neurogenesis
      1. Neural Stem Cells
        1. Stem Cell Properties
          1. Self-Renewal
            1. Multipotency
              1. Asymmetric Division
              2. Stem Cell Niches
                1. Niche Components
                  1. Signaling Regulation
                2. Progenitor Cell Types
                  1. Neuroepithelial Cells
                    1. Radial Glial Cells
                      1. Intermediate Progenitors
                        1. Outer Radial Glia
                        2. Proliferative Zones
                          1. Ventricular Zone
                            1. Location and Structure
                              1. Cell Cycle Dynamics
                              2. Subventricular Zone
                                1. Mammalian Expansion
                                  1. Progenitor Diversity
                                2. Cell Division Modes
                                  1. Symmetric Proliferative Division
                                    1. Asymmetric Neurogenic Division
                                      1. Symmetric Differentiative Division
                                      2. Cell Cycle Regulation
                                        1. G1/S Checkpoint
                                          1. G2/M Checkpoint
                                            1. Cyclins and CDKs
                                              1. Cell Cycle Exit
                                              2. Neuronal Birth Dating
                                                1. Thymidine Labeling
                                                  1. BrdU Incorporation
                                                    1. Temporal Patterns
                                                  2. Gliogenesis
                                                    1. Glial Cell Origins
                                                      1. CNS Glia from Neural Tube
                                                        1. PNS Glia from Neural Crest
                                                        2. Astrocyte Development
                                                          1. Specification Mechanisms
                                                            1. Morphological Maturation
                                                              1. Functional Specialization
                                                              2. Oligodendrocyte Development
                                                                1. Specification from OPCs
                                                                  1. Migration and Differentiation
                                                                    1. Myelination Initiation
                                                                    2. Microglial Development
                                                                      1. Yolk Sac Origin
                                                                        1. CNS Colonization
                                                                          1. Activation States
                                                                          2. Temporal Regulation
                                                                            1. Neurogenesis-Gliogenesis Switch
                                                                              1. Molecular Mechanisms
                                                                            2. Neuronal Migration
                                                                              1. Radial Migration Mechanisms
                                                                                1. Radial Glial Scaffolds
                                                                                  1. Locomotion Modes
                                                                                    1. Somal Translocation
                                                                                      1. Glial-Guided Locomotion
                                                                                      2. Inside-Out Layering
                                                                                      3. Tangential Migration
                                                                                        1. Interneuron Migration
                                                                                          1. Ganglionic Eminence Origins
                                                                                            1. Migration Streams
                                                                                            2. Molecular Control
                                                                                              1. Reelin Signaling
                                                                                                1. Reelin Expression
                                                                                                  1. ApoER2 and VLDLR Receptors
                                                                                                    1. Dab1 Signaling
                                                                                                    2. Cell Adhesion Molecules
                                                                                                      1. N-CAM
                                                                                                        1. L1-CAM
                                                                                                          1. Integrins
                                                                                                          2. Cytoskeletal Regulation
                                                                                                            1. Microtubule Dynamics
                                                                                                              1. Actin Polymerization
                                                                                                            2. Migration Disorders
                                                                                                              1. Lissencephaly
                                                                                                                1. Periventricular Heterotopia
                                                                                                                  1. Double Cortex Syndrome
                                                                                                                2. Cell Fate Determination
                                                                                                                  1. Intrinsic Mechanisms
                                                                                                                    1. Transcription Factor Networks
                                                                                                                      1. Basic Helix-Loop-Helix Factors
                                                                                                                        1. Homeodomain Proteins
                                                                                                                          1. Zinc Finger Proteins
                                                                                                                          2. Epigenetic Regulation
                                                                                                                            1. DNA Methylation
                                                                                                                              1. Histone Modifications
                                                                                                                                1. Chromatin Remodeling
                                                                                                                              2. Extrinsic Signaling
                                                                                                                                1. Morphogen Gradients
                                                                                                                                  1. Concentration Thresholds
                                                                                                                                    1. Temporal Integration
                                                                                                                                    2. Cell-Cell Signaling
                                                                                                                                      1. Notch-Delta Signaling
                                                                                                                                        1. Lateral Inhibition
                                                                                                                                          1. Boundary Formation
                                                                                                                                        2. Neuronal Subtype Specification
                                                                                                                                          1. Excitatory Neuron Types
                                                                                                                                            1. Inhibitory Neuron Types
                                                                                                                                              1. Neurotransmitter Identity
                                                                                                                                              2. Glial Subtype Specification
                                                                                                                                                1. Astrocyte Heterogeneity
                                                                                                                                                  1. Oligodendrocyte Subtypes

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                                                                                                                                              2. Early Neural Development

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                                                                                                                                              4. Neural Circuit Formation