Neural Development

  1. Early Neural Development
    1. Gastrulation and Germ Layer Formation
      1. Gastrulation Overview
        1. Cell Movement Patterns
          1. Morphogenetic Processes
          2. Ectoderm Formation
            1. Neural Ectoderm Specification
              1. Epidermal Ectoderm Fate
                1. Neural Crest Specification
                2. Mesoderm Development
                  1. Notochord Formation
                    1. Somitogenesis
                      1. Lateral Plate Mesoderm
                      2. Endoderm Contribution
                        1. Signaling Role
                          1. Pharyngeal Development
                        2. Neural Induction
                          1. Historical Foundation
                            1. Spemann-Mangold Experiments
                              1. Organizer Concept
                              2. Molecular Mechanisms
                                1. Default Model of Neural Induction
                                  1. BMP Signaling Pathway
                                    1. BMP Ligands
                                      1. BMP Receptors
                                        1. Smad Signaling
                                        2. BMP Antagonists
                                          1. Noggin
                                            1. Chordin
                                              1. Follistatin
                                                1. Cerberus
                                              2. Neural Plate Formation
                                                1. Morphological Changes
                                                  1. Gene Expression Patterns
                                                    1. Regional Specification
                                                    2. Neural Border Establishment
                                                      1. Border Formation Mechanisms
                                                        1. Neural Crest Induction
                                                      2. Neurulation
                                                        1. Primary Neurulation
                                                          1. Neural Plate Shaping
                                                            1. Neural Groove Formation
                                                              1. Neural Fold Elevation
                                                                1. Neural Tube Closure
                                                                  1. Closure Initiation Sites
                                                                    1. Closure Progression
                                                                      1. Molecular Mechanisms
                                                                    2. Secondary Neurulation
                                                                      1. Tail Bud Formation
                                                                        1. Cavitation Process
                                                                        2. Neural Tube Defects
                                                                          1. Anencephaly
                                                                            1. Spina Bifida
                                                                              1. Craniorachischisis
                                                                              2. Neural Crest Development
                                                                                1. Specification Mechanisms
                                                                                  1. Epithelial-Mesenchymal Transition
                                                                                    1. Migration Streams
                                                                                      1. Derivative Cell Types
                                                                                        1. Peripheral Neurons
                                                                                          1. Schwann Cells
                                                                                            1. Melanocytes
                                                                                              1. Craniofacial Structures
                                                                                          2. Neural Tube Patterning
                                                                                            1. Anteroposterior Axis Patterning
                                                                                              1. Primary Brain Vesicles
                                                                                                1. Prosencephalon
                                                                                                  1. Mesencephalon
                                                                                                    1. Rhombencephalon
                                                                                                    2. Secondary Brain Vesicles
                                                                                                      1. Telencephalon
                                                                                                        1. Diencephalon
                                                                                                          1. Metencephalon
                                                                                                            1. Myelencephalon
                                                                                                            2. Hindbrain Segmentation
                                                                                                              1. Rhombomere Formation
                                                                                                                1. Hox Gene Expression
                                                                                                                  1. Segmental Identity
                                                                                                                  2. Signaling Centers
                                                                                                                    1. Anterior Neural Ridge
                                                                                                                      1. Zona Limitans Intrathalamica
                                                                                                                        1. Isthmic Organizer
                                                                                                                          1. Rhombic Lip
                                                                                                                        2. Dorsoventral Axis Patterning
                                                                                                                          1. Ventral Patterning
                                                                                                                            1. Sonic Hedgehog Signaling
                                                                                                                              1. Floor Plate Development
                                                                                                                                1. Motor Neuron Specification
                                                                                                                                2. Dorsal Patterning
                                                                                                                                  1. BMP Signaling
                                                                                                                                    1. Roof Plate Development
                                                                                                                                      1. Interneuron Specification
                                                                                                                                      2. Progenitor Domain Organization
                                                                                                                                        1. Transcriptional Codes
                                                                                                                                          1. Cross-Repressive Interactions
                                                                                                                                            1. Temporal Dynamics

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                                                                                                                                      1. Foundations of Neural Development

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                                                                                                                                      3. Cellular Mechanisms of Neural Development