Human Genetics

  1. Complex Disease Genetics
    1. Multifactorial Inheritance
      1. Polygenic Models
        1. Additive Effects
          1. Quantitative Traits
            1. Heritability Estimates
              1. Twin Studies
              2. Gene-Environment Interactions
                1. Environmental Risk Factors
                  1. Interaction Models
                    1. Phenotypic Plasticity
                      1. Epigenetic Effects
                      2. Threshold Models
                        1. Liability Distributions
                          1. Risk Thresholds
                            1. Recurrence Risks
                              1. Familial Clustering
                            2. Disease Gene Identification
                              1. Linkage Analysis
                                1. Parametric Linkage
                                  1. Non-parametric Linkage
                                    1. Linkage Heterogeneity
                                      1. Fine Mapping
                                      2. Association Studies
                                        1. Case-Control Design
                                          1. Genome-Wide Association Studies
                                            1. Population Stratification
                                              1. Multiple Testing Correction
                                              2. Functional Studies
                                                1. Candidate Gene Approaches
                                                  1. Pathway Analysis
                                                    1. Functional Validation
                                                      1. Model Systems
                                                    2. Common Complex Diseases
                                                      1. Cardiovascular Disease
                                                        1. Genetic Risk Factors
                                                          1. Environmental Contributions
                                                            1. Gene-Environment Interactions
                                                              1. Pharmacogenomic Applications
                                                              2. Metabolic Disorders
                                                                1. Type 2 Diabetes
                                                                  1. Obesity
                                                                    1. Metabolic Syndrome
                                                                      1. Lipid Disorders
                                                                      2. Neurological Disorders
                                                                        1. Alzheimer Disease
                                                                          1. Parkinson Disease
                                                                            1. Multiple Sclerosis
                                                                              1. Stroke
                                                                              2. Psychiatric Disorders
                                                                                1. Schizophrenia
                                                                                  1. Bipolar Disorder
                                                                                    1. Major Depression
                                                                                      1. Autism Spectrum Disorders
                                                                                      2. Autoimmune Diseases
                                                                                        1. Rheumatoid Arthritis
                                                                                          1. Type 1 Diabetes
                                                                                            1. Inflammatory Bowel Disease
                                                                                              1. Systemic Lupus Erythematosus

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                                                                                          6. Population Genetics

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                                                                                          8. Cancer Genetics