Gene Editing

8.

Applications in Biomedical Research

8.1.

Functional Genomics Studies

8.1.1.

Gene Function Analysis

8.1.1.1.

Loss-of-Function Studies

8.1.1.1.1.

Gene Knockout Models

8.1.1.1.2.

Conditional Knockouts

8.1.1.2.

Gain-of-Function Studies

8.1.1.2.1.

Overexpression Systems

8.1.1.2.2.

Activation Approaches

8.1.2.

Genome-Wide Screening

8.1.2.1.

Pooled CRISPR Libraries

8.1.2.1.1.

Library Design Principles

8.1.2.1.2.

Screening Protocols

8.1.2.2.

Essential Gene Identification

8.1.2.2.1.

Fitness Screens

8.1.2.2.2.

Synthetic Lethal Screens

8.1.2.3.

Drug Target Discovery

8.1.2.3.1.

Resistance Screens

8.1.2.3.2.

Sensitization Screens

8.1.3.

Regulatory Element Analysis

8.1.3.1.

Enhancer Identification

8.1.3.2.

Promoter Dissection

8.1.3.3.

Chromatin Architecture Studies

8.2.

Disease Modeling and Research

8.2.1.

Cell Line Development

8.2.1.1.

Isogenic Cell Lines

8.2.1.1.1.

Disease vs. Control Pairs

8.2.1.1.2.

Genetic Background Control

8.2.1.2.

Patient-Derived Models

8.2.1.2.1.

iPSC Generation

8.2.1.2.2.

Disease-specific Mutations

8.2.1.3.

Organoid Systems

8.2.1.3.1.

3D Culture Models

8.2.1.3.2.

Tissue-specific Applications

8.2.2.

Animal Disease Models

8.2.2.1.

8.2.2.1.1.

Knockout and Knock-in Mice

8.2.2.1.2.

Conditional Models

8.2.2.1.3.

Humanized Models

8.2.2.2.

Alternative Model Organisms

8.2.2.2.1.

Zebrafish Models

8.2.2.2.2.

Drosophila Applications

8.2.2.2.3.

C. elegans Studies

8.2.3.

Disease Mechanism Studies

8.2.3.1.

Pathway Analysis

8.2.3.2.

Protein Function Studies

8.2.3.3.

Drug Testing Platforms

8.3.

Biomarker Discovery and Validation

8.3.1.

Therapeutic Target Identification

8.3.2.

Diagnostic Marker Development

8.3.3.

Prognostic Indicator Studies

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7. Gene Editing Workflow and Implementation

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9. Therapeutic Applications