Enzymology

  1. Regulation of Enzyme Activity
    1. Allosteric Regulation
      1. Allosteric Sites and Effectors
        1. Positive Effectors
          1. Negative Effectors
            1. Allosteric Site Location
            2. Homotropic and Heterotropic Effects
              1. Substrate as Effector
                1. Non-Substrate Effectors
                  1. Cooperative Effects
                  2. Models of Allostery
                    1. Concerted Model
                      1. Tense and Relaxed States
                        1. All-or-None Transitions
                        2. Sequential Model
                          1. Stepwise Conformational Changes
                            1. Induced Fit in Allostery
                          2. Sigmoidal Kinetics
                            1. Cooperative Binding
                              1. Hill Coefficient
                                1. Physiological Significance
                              2. Covalent Modification
                                1. Phosphorylation and Dephosphorylation
                                  1. Protein Kinases
                                    1. Protein Phosphatases
                                      1. Serine/Threonine Phosphorylation
                                        1. Tyrosine Phosphorylation
                                        2. Acetylation
                                          1. Lysine Acetylation
                                            1. Acetyltransferases
                                              1. Deacetylases
                                              2. Methylation
                                                1. Arginine Methylation
                                                  1. Lysine Methylation
                                                    1. Methyltransferases
                                                    2. Ubiquitination
                                                      1. Protein Degradation Signals
                                                        1. Ubiquitin-Proteasome System
                                                        2. Other Modifications
                                                          1. Sumoylation
                                                            1. Nitrosylation
                                                              1. Glycosylation
                                                            2. Proteolytic Activation
                                                              1. Zymogens
                                                                1. Mechanism of Activation
                                                                  1. Structural Changes
                                                                  2. Activation Cascades
                                                                    1. Blood Clotting Cascade
                                                                      1. Complement System
                                                                        1. Digestive Enzymes
                                                                        2. Compartmentalization
                                                                        3. Feedback Inhibition and Product Inhibition
                                                                          1. End-Product Inhibition
                                                                            1. Regulation of Metabolic Pathways
                                                                              1. Metabolic Control Theory
                                                                              2. Control of Enzyme Concentration
                                                                                1. Regulation of Gene Expression
                                                                                  1. Transcriptional Control
                                                                                    1. Post-Transcriptional Control
                                                                                      1. Translational Control
                                                                                        1. Enzyme Induction
                                                                                          1. Enzyme Repression
                                                                                          2. Regulation of Protein Degradation
                                                                                            1. Proteasome Pathway
                                                                                              1. Lysosomal Degradation
                                                                                                1. Protein Half-Life

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                                                                                            4. Enzyme Kinetics

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                                                                                            6. Enzymes in Biological Context