Developmental Biology

  1. Cellular Differentiation Mechanisms
    1. Gene Expression Control
      1. Transcriptional Regulation
        1. Transcription Factors
          1. DNA-Binding Domains
            1. Activation Domains
              1. Regulatory Networks
              2. Cis-Regulatory Elements
                1. Promoters
                  1. Enhancers
                    1. Silencers
                    2. Chromatin Regulation
                      1. DNA Methylation
                        1. Histone Modifications
                          1. Chromatin Remodeling
                        2. Post-Transcriptional Control
                          1. Alternative Splicing
                            1. mRNA Localization
                              1. mRNA Stability
                                1. microRNA Regulation
                                2. Translational Control
                                  1. Initiation Factors
                                    1. Ribosome Regulation
                                      1. Upstream ORFs
                                      2. Post-Translational Control
                                        1. Protein Modifications
                                          1. Protein Degradation
                                            1. Subcellular Localization
                                          2. Cell Communication
                                            1. Inductive Interactions
                                              1. Primary Induction
                                                1. Secondary Induction
                                                  1. Competence Windows
                                                  2. Signaling Modes
                                                    1. Paracrine Signaling
                                                      1. Juxtacrine Signaling
                                                        1. Endocrine Signaling
                                                          1. Autocrine Signaling
                                                          2. Major Signaling Pathways
                                                            1. Wnt Signaling
                                                              1. Canonical Pathway
                                                                1. Non-Canonical Pathways
                                                                  1. Target Genes
                                                                  2. TGF-β Superfamily
                                                                    1. BMP Signaling
                                                                      1. Activin/Nodal Signaling
                                                                        1. Smad Proteins
                                                                        2. Hedgehog Signaling
                                                                          1. Sonic Hedgehog
                                                                            1. Signal Transduction
                                                                              1. Target Genes
                                                                              2. RTK Signaling
                                                                                1. FGF Signaling
                                                                                  1. EGF Signaling
                                                                                    1. PDGF Signaling
                                                                                    2. Notch Signaling
                                                                                      1. Lateral Inhibition
                                                                                        1. Binary Cell Fate
                                                                                          1. Boundary Formation
                                                                                      2. Morphogen Gradients
                                                                                        1. Morphogen Concept
                                                                                          1. French Flag Model
                                                                                            1. Gradient Formation
                                                                                              1. Source and Sink
                                                                                                1. Diffusion and Degradation
                                                                                                  1. Active Transport
                                                                                                  2. Gradient Interpretation
                                                                                                    1. Threshold Responses
                                                                                                      1. Concentration Sensing
                                                                                                        1. Temporal Integration
                                                                                                        2. Examples
                                                                                                          1. Bicoid in Drosophila
                                                                                                            1. Hedgehog in Limb
                                                                                                              1. BMP in Dorsal-Ventral Axis

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                                                                                                          4. Body Axis Formation and Patterning

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                                                                                                          6. Morphogenesis and Tissue Formation