Developmental Biology

  1. Body Axis Formation and Patterning
    1. Axis Establishment
      1. Anterior-Posterior Axis
        1. Early Determinants
          1. Maternal Gradients
            1. Zygotic Patterning
            2. Dorsal-Ventral Axis
              1. Symmetry Breaking
                1. Organizer Function
                  1. Gradient Formation
                  2. Left-Right Axis
                    1. Molecular Asymmetry
                      1. Nodal Flow
                        1. Asymmetric Gene Expression
                      2. Maternal Contributions
                        1. Cytoplasmic Determinants
                          1. Maternal Effect Genes
                            1. mRNA Localization
                              1. Protein Gradients
                              2. Organizer Regions
                                1. Spemann-Mangold Organizer
                                  1. Discovery
                                    1. Molecular Identity
                                      1. Signaling Functions
                                      2. Equivalent Organizers
                                        1. Node in Mammals
                                          1. Shield in Zebrafish
                                            1. Hensen's Node in Chick
                                          2. Anterior-Posterior Patterning
                                            1. Hox Gene Clusters
                                              1. Gene Organization
                                                1. Functional Domains
                                                  1. Regulatory Elements
                                                  2. Hox Code
                                                    1. Positional Identity
                                                      1. Combinatorial Expression
                                                      2. Colinearity
                                                        1. Spatial Colinearity
                                                          1. Temporal Colinearity
                                                            1. Evolutionary Conservation
                                                          2. Dorsal-Ventral Patterning
                                                            1. BMP Signaling
                                                              1. Gradient Formation
                                                                1. Target Genes
                                                                  1. Feedback Regulation
                                                                  2. BMP Antagonists
                                                                    1. Chordin
                                                                      1. Noggin
                                                                        1. Follistatin
                                                                        2. Transcriptional Networks
                                                                          1. Dorsal Genes
                                                                            1. Ventral Genes
                                                                              1. Boundary Formation
                                                                            2. Left-Right Asymmetry
                                                                              1. Nodal Signaling
                                                                                1. Asymmetric Expression
                                                                                  1. Signaling Cascade
                                                                                  2. Cilia Function
                                                                                    1. Nodal Flow
                                                                                      1. Mechanosensing
                                                                                      2. Organ Positioning
                                                                                        1. Heart Looping
                                                                                          1. Gut Rotation
                                                                                            1. Brain Asymmetry

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                                                                                        3. Early Embryonic Development

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                                                                                        5. Cellular Differentiation Mechanisms