Cell and Tissue Engineering

  1. Fundamental Cell Biology for Tissue Engineering
    1. The Eukaryotic Cell
      1. Cell Structure and Organization
        1. Nucleus
          1. Nuclear Envelope
            1. Chromatin Organization
              1. Nuclear Pores
              2. Mitochondria
                1. Structure and Function
                  1. Energy Production
                    1. Cellular Respiration
                    2. Endoplasmic Reticulum
                      1. Rough ER
                        1. Smooth ER
                          1. Protein Synthesis and Processing
                          2. Golgi Apparatus
                            1. Structure and Function
                              1. Protein Modification
                                1. Vesicle Transport
                                2. Lysosomes and Peroxisomes
                                  1. Digestive Functions
                                    1. Cellular Cleanup
                                    2. Cytoskeleton
                                      1. Microfilaments
                                        1. Intermediate Filaments
                                          1. Microtubules
                                            1. Cell Shape and Movement
                                            2. Plasma Membrane
                                              1. Membrane Structure
                                                1. Transport Mechanisms
                                                  1. Membrane Proteins
                                                2. Cell Cycle and Proliferation
                                                  1. Phases of the Cell Cycle
                                                    1. G1 Phase
                                                      1. S Phase
                                                        1. G2 Phase
                                                          1. M Phase
                                                          2. Cell Cycle Regulation
                                                            1. Cyclins and Cyclin-Dependent Kinases
                                                              1. Checkpoints
                                                                1. Growth Factors
                                                                2. Cell Division
                                                                  1. Mitosis
                                                                    1. Cytokinesis
                                                                    2. Cell Death
                                                                      1. Apoptosis
                                                                        1. Necrosis
                                                                          1. Autophagy
                                                                          2. Cell Senescence
                                                                            1. Mechanisms
                                                                              1. Implications for Tissue Engineering
                                                                            2. Cell Differentiation and Specialization
                                                                              1. Mechanisms of Differentiation
                                                                                1. Gene Expression Regulation
                                                                                  1. Transcription Factors
                                                                                    1. Epigenetic Modifications
                                                                                    2. Lineage Commitment
                                                                                      1. Stem Cell Differentiation
                                                                                        1. Developmental Pathways
                                                                                        2. Maintenance of Cell Phenotype
                                                                                          1. Phenotypic Stability
                                                                                            1. Dedifferentiation
                                                                                        3. The Extracellular Matrix
                                                                                          1. ECM Composition
                                                                                            1. Collagens
                                                                                              1. Types of Collagen
                                                                                                1. Collagen Structure
                                                                                                  1. Collagen Synthesis
                                                                                                    1. Collagen Assembly
                                                                                                    2. Elastin
                                                                                                      1. Structure and Properties
                                                                                                        1. Elastic Fiber Formation
                                                                                                          1. Tissue Elasticity
                                                                                                          2. Proteoglycans
                                                                                                            1. Core Proteins
                                                                                                              1. Glycosaminoglycans
                                                                                                                1. Hydration and Compression Resistance
                                                                                                                2. Glycoproteins
                                                                                                                  1. Fibronectin
                                                                                                                    1. Structure and Domains
                                                                                                                      1. Cell Binding Sites
                                                                                                                      2. Laminin
                                                                                                                        1. Basement Membrane Component
                                                                                                                          1. Cell Adhesion Functions
                                                                                                                          2. Vitronectin
                                                                                                                            1. Thrombospondin
                                                                                                                          3. ECM Functions
                                                                                                                            1. Structural Support
                                                                                                                              1. Mechanical Properties
                                                                                                                                1. Tissue Architecture
                                                                                                                                2. Cell Behavior Regulation
                                                                                                                                  1. Cell Adhesion
                                                                                                                                    1. Cell Migration
                                                                                                                                      1. Cell Proliferation
                                                                                                                                        1. Cell Differentiation
                                                                                                                                        2. ECM Remodeling
                                                                                                                                          1. Matrix Metalloproteinases
                                                                                                                                            1. Tissue Inhibitors of Metalloproteinases
                                                                                                                                              1. Dynamic Remodeling
                                                                                                                                            2. Tissue-Specific ECM
                                                                                                                                              1. Bone Matrix
                                                                                                                                                1. Cartilage Matrix
                                                                                                                                                  1. Skin Matrix
                                                                                                                                                    1. Vascular Matrix
                                                                                                                                                  2. Cell-Cell and Cell-Matrix Interactions
                                                                                                                                                    1. Cell Adhesion Molecules
                                                                                                                                                      1. Cadherins
                                                                                                                                                        1. E-Cadherin
                                                                                                                                                          1. N-Cadherin
                                                                                                                                                            1. Adherens Junctions
                                                                                                                                                            2. Selectins
                                                                                                                                                              1. E-Selectin
                                                                                                                                                                1. P-Selectin
                                                                                                                                                                  1. L-Selectin
                                                                                                                                                                  2. Immunoglobulin Superfamily
                                                                                                                                                                    1. ICAM
                                                                                                                                                                      1. VCAM
                                                                                                                                                                        1. NCAM
                                                                                                                                                                      2. Integrins and Cell-Matrix Adhesion
                                                                                                                                                                        1. Integrin Structure
                                                                                                                                                                          1. Alpha Subunits
                                                                                                                                                                            1. Beta Subunits
                                                                                                                                                                              1. Heterodimer Formation
                                                                                                                                                                              2. Integrin Function
                                                                                                                                                                                1. ECM Binding
                                                                                                                                                                                  1. Signal Transduction
                                                                                                                                                                                  2. Focal Adhesions
                                                                                                                                                                                    1. Focal Adhesion Complexes
                                                                                                                                                                                      1. Signaling Pathways
                                                                                                                                                                                        1. Mechanotransduction
                                                                                                                                                                                      2. Cell-Cell Communication
                                                                                                                                                                                        1. Gap Junctions
                                                                                                                                                                                          1. Connexins
                                                                                                                                                                                            1. Intercellular Communication
                                                                                                                                                                                              1. Tissue Coordination
                                                                                                                                                                                              2. Tight Junctions
                                                                                                                                                                                                1. Barrier Function
                                                                                                                                                                                                  1. Cell Polarity
                                                                                                                                                                                                  2. Paracrine Signaling
                                                                                                                                                                                                    1. Growth Factors
                                                                                                                                                                                                      1. Cytokines

                                                                                                                                                                                                Previous

                                                                                                                                                                                                1. Introduction to Cell and Tissue Engineering

                                                                                                                                                                                                Go to top

                                                                                                                                                                                                Next

                                                                                                                                                                                                3. Cell Sources and Manipulation