Allergy and Immunology

  1. Immunodeficiency Disorders
    1. Primary Immunodeficiencies
      1. Classification Systems
        1. Functional Classification
          1. Cellular Defect Classification
            1. Clinical Presentation Patterns
            2. Predominantly Antibody Deficiencies
              1. X-linked Agammaglobulinemia
                1. BTK Gene Mutations
                  1. Clinical Features
                    1. Laboratory Findings
                      1. Treatment Approaches
                      2. Common Variable Immunodeficiency
                        1. Heterogeneous Causes
                          1. Clinical Presentation
                            1. Associated Conditions
                              1. Management Strategies
                              2. Selective IgA Deficiency
                                1. Prevalence and Genetics
                                  1. Clinical Associations
                                    1. Transfusion Considerations
                                    2. Specific Antibody Deficiency
                                      1. Functional Assessment
                                        1. Clinical Features
                                      2. Combined Immunodeficiencies
                                        1. Severe Combined Immunodeficiency
                                          1. Genetic Subtypes
                                            1. Clinical Presentation
                                              1. Screening Programs
                                                1. Treatment Options
                                                2. DiGeorge Syndrome
                                                  1. 22q11.2 Deletion
                                                    1. Clinical Features
                                                      1. Immunological Defects
                                                        1. Management Approaches
                                                        2. Wiskott-Aldrich Syndrome
                                                          1. WASP Gene Mutations
                                                            1. Clinical Triad
                                                              1. Complications
                                                            2. Phagocyte Defects
                                                              1. Chronic Granulomatous Disease
                                                                1. NADPH Oxidase Defects
                                                                  1. Clinical Features
                                                                    1. Diagnostic Tests
                                                                      1. Treatment Strategies
                                                                      2. Leukocyte Adhesion Deficiency
                                                                        1. Integrin Defects
                                                                          1. Clinical Presentation
                                                                            1. Laboratory Findings
                                                                          2. Complement Deficiencies
                                                                            1. Early Component Deficiencies
                                                                              1. Autoimmune Associations
                                                                                1. Infection Susceptibility
                                                                                2. Late Component Deficiencies
                                                                                  1. Neisserial Infections
                                                                                    1. Clinical Features
                                                                                    2. Regulatory Protein Deficiencies
                                                                                      1. Hereditary Angioedema
                                                                                        1. Atypical Hemolytic Uremic Syndrome
                                                                                    3. Secondary Immunodeficiencies
                                                                                      1. HIV/AIDS
                                                                                        1. Viral Pathogenesis
                                                                                          1. CD4+ T-cell Depletion
                                                                                            1. Immune System Dysfunction
                                                                                            2. Clinical Stages
                                                                                              1. Acute HIV Syndrome
                                                                                                1. Chronic HIV Infection
                                                                                                  1. AIDS-defining Conditions
                                                                                                  2. Opportunistic Infections
                                                                                                    1. Bacterial Infections
                                                                                                      1. Viral Infections
                                                                                                        1. Fungal Infections
                                                                                                          1. Parasitic Infections
                                                                                                        2. Malignancy-associated Immunodeficiency
                                                                                                          1. Hematological Malignancies
                                                                                                            1. Leukemia Effects
                                                                                                              1. Lymphoma Effects
                                                                                                                1. Multiple Myeloma
                                                                                                                2. Solid Tumors
                                                                                                                  1. Immune Suppression Mechanisms
                                                                                                                3. Iatrogenic Immunodeficiency
                                                                                                                  1. Chemotherapy Effects
                                                                                                                    1. Neutropenia
                                                                                                                      1. Lymphopenia
                                                                                                                        1. Recovery Patterns
                                                                                                                        2. Immunosuppressive Medications
                                                                                                                          1. Corticosteroids
                                                                                                                            1. Calcineurin Inhibitors
                                                                                                                              1. Antimetabolites
                                                                                                                                1. Biologics
                                                                                                                              2. Other Causes
                                                                                                                                1. Malnutrition
                                                                                                                                  1. Protein-energy Malnutrition
                                                                                                                                    1. Micronutrient Deficiencies
                                                                                                                                    2. Chronic Diseases
                                                                                                                                      1. Diabetes Mellitus
                                                                                                                                        1. Chronic Kidney Disease
                                                                                                                                          1. Liver Disease

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                                                                                                                                    4. Autoimmune Diseases

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                                                                                                                                    6. Diagnostic Evaluation