Allergy and Immunology

  1. Clinical Allergic Disorders
    1. Respiratory Allergies
      1. Allergic Rhinitis
        1. Seasonal vs Perennial
          1. Pathophysiology
            1. Early Phase Response
              1. Late Phase Response
              2. Clinical Symptoms
                1. Nasal Symptoms
                  1. Ocular Symptoms
                    1. Associated Features
                    2. Common Triggers
                      1. Pollen Allergens
                        1. Dust Mites
                          1. Animal Dander
                            1. Mold Spores
                          2. Allergic Conjunctivitis
                            1. Clinical Features
                              1. Itching and Tearing
                                1. Conjunctival Injection
                                  1. Chemosis
                                  2. Seasonal vs Perennial Forms
                                    1. Differential Diagnosis
                                      1. Infectious Conjunctivitis
                                        1. Dry Eye Syndrome
                                      2. Allergic Asthma
                                        1. Pathogenesis
                                          1. Airway Inflammation
                                            1. Bronchial Hyperresponsiveness
                                              1. Airway Remodeling
                                              2. Clinical Presentation
                                                1. Wheezing
                                                  1. Dyspnea
                                                    1. Chest Tightness
                                                      1. Cough
                                                      2. Triggers
                                                        1. Aeroallergens
                                                          1. Exercise
                                                            1. Cold Air
                                                              1. Irritants
                                                              2. Phenotypes
                                                                1. Allergic Asthma
                                                                  1. Non-allergic Asthma
                                                                    1. Mixed Patterns
                                                                  2. Allergic Bronchopulmonary Aspergillosis
                                                                    1. Pathophysiology
                                                                      1. Hypersensitivity to Aspergillus
                                                                        1. Bronchiectasis Development
                                                                        2. Diagnostic Criteria
                                                                          1. Clinical Features
                                                                            1. Laboratory Findings
                                                                              1. Radiological Changes
                                                                          2. Cutaneous Allergies
                                                                            1. Atopic Dermatitis
                                                                              1. Clinical Presentation
                                                                                1. Distribution of Lesions
                                                                                  1. Morphology Changes
                                                                                  2. Pathogenesis
                                                                                    1. Barrier Dysfunction
                                                                                      1. Immune Dysregulation
                                                                                        1. Environmental Factors
                                                                                        2. Complications
                                                                                          1. Secondary Infections
                                                                                            1. Eczema Herpeticum
                                                                                              1. Contact Sensitization
                                                                                            2. Urticaria and Angioedema
                                                                                              1. Acute Urticaria
                                                                                                1. Duration and Triggers
                                                                                                  1. Clinical Features
                                                                                                  2. Chronic Urticaria
                                                                                                    1. Spontaneous vs Inducible
                                                                                                      1. Autoimmune Mechanisms
                                                                                                      2. Angioedema
                                                                                                        1. Distribution Patterns
                                                                                                          1. Hereditary vs Acquired
                                                                                                          2. Physical Urticarias
                                                                                                            1. Cold Urticaria
                                                                                                              1. Cholinergic Urticaria
                                                                                                                1. Pressure Urticaria
                                                                                                                  1. Solar Urticaria
                                                                                                                2. Contact Dermatitis
                                                                                                                  1. Allergic Contact Dermatitis
                                                                                                                    1. Sensitization Process
                                                                                                                      1. Common Allergens
                                                                                                                        1. Clinical Patterns
                                                                                                                        2. Irritant Contact Dermatitis
                                                                                                                          1. Mechanism Differences
                                                                                                                            1. Clinical Features
                                                                                                                            2. Patch Testing
                                                                                                                              1. Standard Series
                                                                                                                                1. Interpretation
                                                                                                                            3. Food Allergies
                                                                                                                              1. IgE-mediated Food Allergies
                                                                                                                                1. Common Food Allergens
                                                                                                                                  1. Milk
                                                                                                                                    1. Egg
                                                                                                                                      1. Peanut
                                                                                                                                        1. Tree Nuts
                                                                                                                                          1. Soy
                                                                                                                                            1. Wheat
                                                                                                                                              1. Fish
                                                                                                                                                1. Shellfish
                                                                                                                                                2. Clinical Manifestations
                                                                                                                                                  1. Gastrointestinal Symptoms
                                                                                                                                                    1. Cutaneous Symptoms
                                                                                                                                                      1. Respiratory Symptoms
                                                                                                                                                        1. Systemic Anaphylaxis
                                                                                                                                                        2. Natural History
                                                                                                                                                          1. Outgrowing Food Allergies
                                                                                                                                                            1. Persistent Allergies
                                                                                                                                                          2. Non-IgE-mediated Food Allergies
                                                                                                                                                            1. Food Protein-induced Enterocolitis Syndrome
                                                                                                                                                              1. Clinical Presentation
                                                                                                                                                                1. Trigger Foods
                                                                                                                                                                  1. Diagnostic Approach
                                                                                                                                                                  2. Food Protein-induced Allergic Proctocolitis
                                                                                                                                                                    1. Clinical Features
                                                                                                                                                                      1. Management
                                                                                                                                                                    2. Mixed IgE and Non-IgE Reactions
                                                                                                                                                                      1. Eosinophilic Esophagitis
                                                                                                                                                                        1. Pathogenesis
                                                                                                                                                                          1. Clinical Features
                                                                                                                                                                            1. Diagnostic Criteria
                                                                                                                                                                            2. Eosinophilic Gastroenteritis
                                                                                                                                                                              1. Clinical Presentation
                                                                                                                                                                                1. Diagnostic Approach
                                                                                                                                                                              2. Food Intolerance vs Allergy
                                                                                                                                                                                1. Lactose Intolerance
                                                                                                                                                                                  1. Food Additives
                                                                                                                                                                                    1. Histamine Intolerance
                                                                                                                                                                                  2. Drug Hypersensitivity
                                                                                                                                                                                    1. Classification Systems
                                                                                                                                                                                      1. Immunological vs Non-immunological
                                                                                                                                                                                        1. Timing of Reactions
                                                                                                                                                                                        2. IgE-mediated Reactions
                                                                                                                                                                                          1. Beta-lactam Antibiotics
                                                                                                                                                                                            1. Other Common Drugs
                                                                                                                                                                                              1. Clinical Manifestations
                                                                                                                                                                                              2. Non-IgE-mediated Reactions
                                                                                                                                                                                                1. T-cell Mediated Reactions
                                                                                                                                                                                                  1. Cytotoxic Reactions
                                                                                                                                                                                                    1. Immune Complex Reactions
                                                                                                                                                                                                    2. Severe Cutaneous Adverse Reactions
                                                                                                                                                                                                      1. Stevens-Johnson Syndrome
                                                                                                                                                                                                        1. Clinical Features
                                                                                                                                                                                                          1. Risk Factors
                                                                                                                                                                                                            1. Pathogenesis
                                                                                                                                                                                                            2. Toxic Epidermal Necrolysis
                                                                                                                                                                                                              1. Clinical Features
                                                                                                                                                                                                                1. Mortality Risk
                                                                                                                                                                                                                  1. Management Principles
                                                                                                                                                                                                                  2. Drug Reaction with Eosinophilia and Systemic Symptoms
                                                                                                                                                                                                                    1. Clinical Features
                                                                                                                                                                                                                      1. Organ Involvement
                                                                                                                                                                                                                  3. Insect Sting Allergies
                                                                                                                                                                                                                    1. Hymenoptera Venom Allergy
                                                                                                                                                                                                                      1. Epidemiology
                                                                                                                                                                                                                        1. Venom Components
                                                                                                                                                                                                                          1. Clinical Manifestations
                                                                                                                                                                                                                            1. Local Reactions
                                                                                                                                                                                                                              1. Systemic Reactions
                                                                                                                                                                                                                                1. Anaphylaxis
                                                                                                                                                                                                                                2. Risk Factors
                                                                                                                                                                                                                                  1. Previous Reactions
                                                                                                                                                                                                                                    1. Atopic Status
                                                                                                                                                                                                                                      1. Age Factors
                                                                                                                                                                                                                                  2. Anaphylaxis
                                                                                                                                                                                                                                    1. Definition and Criteria
                                                                                                                                                                                                                                      1. Clinical Criteria
                                                                                                                                                                                                                                        1. Biphasic Reactions
                                                                                                                                                                                                                                        2. Pathophysiology
                                                                                                                                                                                                                                          1. Mediator Release
                                                                                                                                                                                                                                            1. Cardiovascular Effects
                                                                                                                                                                                                                                              1. Respiratory Effects
                                                                                                                                                                                                                                              2. Common Triggers
                                                                                                                                                                                                                                                1. Foods
                                                                                                                                                                                                                                                  1. Medications
                                                                                                                                                                                                                                                    1. Insect Stings
                                                                                                                                                                                                                                                      1. Exercise
                                                                                                                                                                                                                                                        1. Idiopathic Causes
                                                                                                                                                                                                                                                        2. Clinical Presentation
                                                                                                                                                                                                                                                          1. Cutaneous Manifestations
                                                                                                                                                                                                                                                            1. Respiratory Symptoms
                                                                                                                                                                                                                                                              1. Cardiovascular Collapse
                                                                                                                                                                                                                                                                1. Gastrointestinal Symptoms
                                                                                                                                                                                                                                                                2. Emergency Management
                                                                                                                                                                                                                                                                  1. Epinephrine Administration
                                                                                                                                                                                                                                                                    1. Supportive Care
                                                                                                                                                                                                                                                                      1. Hospital Monitoring
                                                                                                                                                                                                                                                                        1. Discharge Planning

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                                                                                                                                                                                                                                                                    2. Hypersensitivity Reactions

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                                                                                                                                                                                                                                                                    4. Autoimmune Diseases