Statistical Genetics and Genomics

  1. Quantitative Genetics
    1. Genetic Architecture of Complex Traits
      1. Types of Complex Traits
        1. Quantitative Traits
          1. Threshold Traits
            1. Polygenic Traits
              1. Oligogenic Traits
              2. Components of Phenotypic Variation
                1. Genetic Effects
                  1. Environmental Effects
                    1. Gene-Environment Interactions
                      1. Gene-Environment Correlations
                      2. Genetic Value Decomposition
                        1. Additive Effects
                          1. Dominance Effects
                            1. Epistatic Effects
                              1. Interaction Effects
                            2. Variance Components Analysis
                              1. Partitioning Phenotypic Variance
                                1. Additive Genetic Variance
                                  1. Dominance Variance
                                    1. Epistatic Variance
                                      1. Environmental Variance
                                      2. Covariance Between Relatives
                                        1. Parent-Offspring Covariance
                                          1. Sibling Covariance
                                            1. Twin Covariance
                                              1. Spouse Covariance
                                            2. Heritability Estimation
                                              1. Broad-Sense Heritability
                                                1. Definition and Interpretation
                                                  1. Calculation Methods
                                                  2. Narrow-Sense Heritability
                                                    1. Definition and Interpretation
                                                      1. Relationship to Response to Selection
                                                      2. Methods for Estimating Heritability
                                                        1. Twin Studies
                                                          1. Classical Twin Model
                                                            1. ACE Models
                                                              1. Extended Twin Models
                                                              2. Family Studies
                                                                1. Nuclear Family Studies
                                                                  1. Extended Pedigree Analysis
                                                                  2. Adoption Studies
                                                                    1. Design and Analysis
                                                                    2. SNP-Based Heritability
                                                                      1. GREML Method
                                                                        1. LD Score Regression
                                                                          1. Genomic Relationship Matrices
                                                                      2. Selection and Breeding
                                                                        1. Response to Selection
                                                                          1. Breeder's Equation
                                                                            1. Selection Differential
                                                                              1. Selection Intensity
                                                                                1. Correlated Response
                                                                                2. Selection Methods
                                                                                  1. Individual Selection
                                                                                    1. Family Selection
                                                                                      1. Within-Family Selection
                                                                                        1. Index Selection
                                                                                        2. Prediction of Breeding Values
                                                                                          1. Best Linear Unbiased Prediction
                                                                                            1. Mixed Model Equations
                                                                                              1. Genomic Selection
                                                                                                1. Marker-Assisted Selection

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                                                                                            2. Population Genetics Principles

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                                                                                            4. Linkage Analysis and Gene Mapping