Statistical Genetics and Genomics

  1. Specialized Applications
    1. Pharmacogenomics
      1. Drug Response Genetics
        1. Pharmacokinetic Genes
          1. Pharmacodynamic Genes
            1. Adverse Drug Reactions
            2. GWAS of Drug Response
              1. Study Design Considerations
                1. Phenotype Definition
                  1. Population Stratification
                  2. Clinical Implementation
                    1. Dosing Guidelines
                      1. Genetic Testing
                        1. Regulatory Considerations
                      2. Cancer Genomics
                        1. Somatic Mutation Analysis
                          1. Tumor vs Normal Comparisons
                            1. Mutation Signatures
                              1. Driver vs Passenger Mutations
                              2. Copy Number Analysis
                                1. Tumor Heterogeneity
                                  1. Clonal Evolution
                                    1. Therapeutic Targets
                                    2. Germline Susceptibility
                                      1. Cancer Predisposition Genes
                                        1. Polygenic Risk Scores
                                          1. Family History Integration
                                        2. Evolutionary Genomics
                                          1. Signatures of Natural Selection
                                            1. Selective Sweeps
                                              1. Balancing Selection
                                                1. Population Differentiation
                                                2. Phylogenetic Analysis
                                                  1. Tree Construction
                                                    1. Molecular Dating
                                                      1. Ancestral Reconstruction
                                                      2. Comparative Genomics
                                                        1. Synteny Analysis
                                                          1. Ortholog Identification
                                                            1. Functional Conservation
                                                          2. Agricultural Genomics
                                                            1. Crop Improvement
                                                              1. Marker-Assisted Selection
                                                                1. Genomic Selection
                                                                  1. Gene Editing Applications
                                                                  2. Livestock Breeding
                                                                    1. Breeding Value Prediction
                                                                      1. Inbreeding Management
                                                                        1. Disease Resistance
                                                                        2. Population Management
                                                                          1. Genetic Diversity Assessment
                                                                            1. Conservation Strategies
                                                                              1. Breeding Program Design

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                                                                          9. Advanced Statistical Methods

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                                                                          11. Computational Tools and Resources