Cellular and Molecular Bioengineering

  1. Advanced and Emerging Topics
    1. Immunobioengineering
      1. Engineering the Immune Response
        1. Antigen Presentation Modulation
          1. MHC Class I and II Pathways
            1. Dendritic Cell Engineering
              1. Antigen Processing Enhancement
              2. Immune Cell Engineering
                1. T Cell Receptor Engineering
                  1. NK Cell Modifications
                    1. Macrophage Polarization
                  2. Vaccine Development and Engineering
                    1. Subunit Vaccines
                      1. Protein Antigen Design
                        1. Adjuvant Selection
                          1. Delivery Systems
                          2. mRNA Vaccines
                            1. mRNA Design and Optimization
                              1. Lipid Nanoparticle Delivery
                                1. Immune Response Mechanisms
                                2. Adjuvant Design
                                  1. Innate Immune Activation
                                    1. Adjuvant Mechanisms
                                      1. Safety Considerations
                                    2. Immuno-modulatory Biomaterials
                                      1. Biomaterial-Immune Interactions
                                        1. Foreign Body Response
                                          1. Biocompatibility Assessment
                                            1. Immune Cell Recruitment
                                            2. Controlled Release of Immunomodulators
                                              1. Cytokine Delivery
                                                1. Immunosuppressive Agents
                                                  1. Temporal Control
                                                2. Engineering Immune Cells
                                                  1. T Cell Engineering
                                                    1. CAR-T Cell Design
                                                      1. TCR Engineering
                                                        1. T Cell Expansion
                                                        2. Dendritic Cell Engineering
                                                          1. Antigen Loading
                                                            1. Maturation Signals
                                                              1. Migration Enhancement
                                                          2. Mechanobiology
                                                            1. Mechanotransduction
                                                              1. Mechanosensitive Ion Channels
                                                                1. Channel Types and Properties
                                                                  1. Gating Mechanisms
                                                                    1. Physiological Roles
                                                                    2. Focal Adhesions
                                                                      1. Integrin Clustering
                                                                        1. Force Transmission
                                                                          1. Signaling Complexes
                                                                        2. Role of Mechanical Forces in Development and Disease
                                                                          1. Embryonic Development
                                                                            1. Morphogenetic Forces
                                                                              1. Tissue Folding and Shaping
                                                                                1. Cell Fate Determination
                                                                                2. Cancer Progression
                                                                                  1. Tumor Mechanics
                                                                                    1. Metastatic Invasion
                                                                                      1. Mechanically-Induced Signaling
                                                                                      2. Fibrosis and Tissue Remodeling
                                                                                        1. Fibroblast Activation
                                                                                          1. ECM Remodeling
                                                                                            1. Mechanical Feedback Loops
                                                                                          2. Engineering the Cellular Mechanical Microenvironment
                                                                                            1. Substrate Stiffness
                                                                                              1. Stiffness Gradients
                                                                                                1. Cell Response to Stiffness
                                                                                                  1. Measurement Techniques
                                                                                                  2. Topographical Cues
                                                                                                    1. Surface Patterning
                                                                                                      1. Nanotopography Effects
                                                                                                        1. Cell Alignment and Migration
                                                                                                        2. Dynamic Mechanical Stimulation
                                                                                                          1. Cyclic Loading
                                                                                                            1. Shear Flow
                                                                                                              1. Stretch and Compression
                                                                                                          2. Computational Bioengineering and Bioinformatics
                                                                                                            1. High-Throughput Data Analysis
                                                                                                              1. Genomics
                                                                                                                1. DNA Sequencing Data Analysis
                                                                                                                  1. Quality Control
                                                                                                                    1. Read Alignment
                                                                                                                      1. Variant Calling
                                                                                                                      2. Variant Calling
                                                                                                                        1. SNP Detection
                                                                                                                          1. Indel Identification
                                                                                                                            1. Structural Variants
                                                                                                                          2. Proteomics
                                                                                                                            1. Mass Spectrometry Data Processing
                                                                                                                              1. Peak Detection
                                                                                                                                1. Peptide Identification
                                                                                                                                  1. Quantification Methods
                                                                                                                                  2. Protein Identification and Quantification
                                                                                                                                    1. Database Searching
                                                                                                                                      1. Statistical Validation
                                                                                                                                        1. Comparative Analysis
                                                                                                                                      2. Metabolomics
                                                                                                                                        1. Metabolite Profiling
                                                                                                                                          1. Sample Preparation
                                                                                                                                            1. Analytical Platforms
                                                                                                                                              1. Data Processing
                                                                                                                                              2. Pathway Mapping
                                                                                                                                                1. Metabolic Network Analysis
                                                                                                                                                  1. Pathway Enrichment
                                                                                                                                                    1. Integration with Other Omics
                                                                                                                                                2. Machine Learning in Biology and Medicine
                                                                                                                                                  1. Supervised Learning Applications
                                                                                                                                                    1. Classification Problems
                                                                                                                                                      1. Regression Analysis
                                                                                                                                                        1. Feature Selection
                                                                                                                                                        2. Unsupervised Learning and Clustering
                                                                                                                                                          1. Dimensionality Reduction
                                                                                                                                                            1. Clustering Algorithms
                                                                                                                                                              1. Pattern Discovery
                                                                                                                                                              2. Deep Learning for Image and Sequence Analysis
                                                                                                                                                                1. Convolutional Neural Networks
                                                                                                                                                                  1. Recurrent Neural Networks
                                                                                                                                                                    1. Transformer Models
                                                                                                                                                                  2. Multiscale Modeling of Biological Systems
                                                                                                                                                                    1. Molecular to Cellular Scale Integration
                                                                                                                                                                      1. Molecular Dynamics
                                                                                                                                                                        1. Cellular Automata
                                                                                                                                                                          1. Agent-Based Models
                                                                                                                                                                          2. Tissue and Organ Level Modeling
                                                                                                                                                                            1. Continuum Mechanics
                                                                                                                                                                              1. Finite Element Methods
                                                                                                                                                                                1. Physiologically-Based Models
                                                                                                                                                                            2. Ethical, Safety, and Regulatory Considerations
                                                                                                                                                                              1. Bioethics in Genetic Engineering and Synthetic Biology
                                                                                                                                                                                1. Human Genome Editing Ethics
                                                                                                                                                                                  1. Germline vs. Somatic Editing
                                                                                                                                                                                    1. Enhancement vs. Treatment
                                                                                                                                                                                    2. Dual-Use Research Concerns
                                                                                                                                                                                      1. Biosecurity Risks
                                                                                                                                                                                        1. Research Oversight
                                                                                                                                                                                          1. Publication Guidelines
                                                                                                                                                                                        2. Safety of Engineered Organisms
                                                                                                                                                                                          1. Containment Strategies
                                                                                                                                                                                            1. Physical Containment
                                                                                                                                                                                              1. Biological Containment
                                                                                                                                                                                                1. Molecular Safeguards
                                                                                                                                                                                                2. Risk Assessment and Management
                                                                                                                                                                                                  1. Hazard Identification
                                                                                                                                                                                                    1. Exposure Assessment
                                                                                                                                                                                                      1. Risk Characterization
                                                                                                                                                                                                    2. Regulatory Pathways for Cell and Gene Therapies
                                                                                                                                                                                                      1. FDA Approval Process
                                                                                                                                                                                                        1. Preclinical Requirements
                                                                                                                                                                                                          1. Clinical Trial Phases
                                                                                                                                                                                                            1. Regulatory Submissions
                                                                                                                                                                                                            2. EMA Regulatory Framework
                                                                                                                                                                                                              1. European Guidelines
                                                                                                                                                                                                                1. Centralized Procedures
                                                                                                                                                                                                                  1. Post-Market Surveillance
                                                                                                                                                                                                                  2. Clinical Trial Design and Oversight
                                                                                                                                                                                                                    1. Protocol Development
                                                                                                                                                                                                                      1. Institutional Review Boards
                                                                                                                                                                                                                        1. Good Clinical Practice

                                                                                                                                                                                                                  Previous

                                                                                                                                                                                                                  4. Applications in Bioengineering

                                                                                                                                                                                                                  Go to top

                                                                                                                                                                                                                  Back to Start

                                                                                                                                                                                                                  1. Foundations of Cellular and Molecular Bioengineering