Biophysics

  1. Cellular Biophysics
    1. Bioelectricity and Excitable Cells
      1. The Nernst and Goldman Equations
        1. Calculation of Equilibrium Potentials
          1. Permeability and Ion Gradients
            1. Relative Permeabilities
            2. Resting Membrane Potential
              1. Ionic Basis
                1. Maintenance by Ion Pumps
                  1. Donnan Equilibrium
                  2. The Action Potential
                    1. Initiation and Threshold
                      1. Ion Channel Gating
                        1. Voltage-Gated Channels
                          1. Ligand-Gated Channels
                            1. Mechanosensitive Channels
                            2. Propagation of Nerve Impulses
                              1. Saltatory Conduction
                                1. Myelination
                                  1. Conduction Velocity
                                  2. The Hodgkin-Huxley Model
                                    1. Model Equations
                                      1. Experimental Validation
                                        1. Computational Implementation
                                      2. Synaptic Transmission
                                        1. Chemical Synapses
                                          1. Electrical Synapses
                                            1. Neurotransmitter Release and Receptors
                                              1. Synaptic Plasticity
                                            2. Cellular Mechanics and the Cytoskeleton
                                              1. Mechanical Properties of Cells
                                                1. Elasticity and Stiffness
                                                  1. Measurement Techniques
                                                    1. Viscoelastic Behavior
                                                    2. Cytoskeletal Filaments
                                                      1. Actin Filaments
                                                        1. Structure and Assembly
                                                          1. Role in Cell Shape and Movement
                                                            1. Actin-Binding Proteins
                                                            2. Microtubules
                                                              1. Structure and Dynamics
                                                                1. Role in Intracellular Transport
                                                                  1. Microtubule-Associated Proteins
                                                                  2. Intermediate Filaments
                                                                    1. Types and Functions
                                                                      1. Mechanical Properties
                                                                    2. Polymerization Dynamics
                                                                      1. Nucleation and Elongation
                                                                        1. Dynamic Instability
                                                                          1. Treadmilling
                                                                            1. Force Generation
                                                                            2. Molecular Motors
                                                                              1. Myosins
                                                                                1. Mechanism of Movement
                                                                                  1. Role in Muscle Contraction
                                                                                    1. Non-Muscle Myosins
                                                                                    2. Kinesins
                                                                                      1. Microtubule-Based Transport
                                                                                        1. Processivity
                                                                                        2. Dyneins
                                                                                          1. Ciliary and Flagellar Motion
                                                                                            1. Cytoplasmic Dynein
                                                                                          2. Cell Motility and Adhesion
                                                                                            1. Mechanisms of Cell Movement
                                                                                              1. Cell-Substrate Interactions
                                                                                                1. Cell-Cell Adhesion
                                                                                                  1. Focal Adhesions
                                                                                                2. Subcellular Organization
                                                                                                  1. Phase Separation and Membraneless Organelles
                                                                                                    1. Principles of Liquid-Liquid Phase Separation
                                                                                                      1. Biological Examples
                                                                                                        1. Regulation of Phase Separation
                                                                                                        2. Intracellular Transport and Trafficking
                                                                                                          1. Vesicular Transport
                                                                                                            1. Motor-Driven Transport
                                                                                                              1. Endocytosis and Exocytosis
                                                                                                              2. Nuclear Mechanics and Organization
                                                                                                                1. Nuclear Envelope Structure
                                                                                                                  1. Chromatin Organization
                                                                                                                    1. Nuclear Pore Complexes
                                                                                                                      1. Nuclear Lamins

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                                                                                                                  3. Molecular Biophysics

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                                                                                                                  5. Systems and Organismal Biophysics