Computational Neuroscience

  1. Synaptic Plasticity and Learning
    1. Short-Term Plasticity
      1. Synaptic Facilitation
        1. Mechanisms
          1. Residual calcium hypothesis
            1. Calcium sensor proteins
            2. Functional significance
              1. Temporal filtering
                1. Information processing
                2. Mathematical models
                  1. Facilitation dynamics
                    1. Recovery kinetics
                  2. Synaptic Depression
                    1. Mechanisms
                      1. Vesicle depletion
                        1. Calcium channel inactivation
                        2. Functional significance
                          1. Adaptation
                            1. Gain control
                            2. Mathematical models
                              1. Depression dynamics
                                1. Resource depletion
                              2. Short-Term Plasticity Interactions
                                1. Facilitation-depression interplay
                                  1. Frequency-dependent filtering
                                    1. Computational roles
                                  2. Long-Term Plasticity
                                    1. Long-Term Potentiation
                                      1. Induction protocols
                                        1. High-frequency stimulation
                                          1. Theta burst stimulation
                                          2. Molecular mechanisms
                                            1. NMDA receptor activation
                                              1. Calcium signaling
                                                1. Protein synthesis
                                                2. Expression mechanisms
                                                  1. AMPA receptor trafficking
                                                    1. Structural changes
                                                  2. Long-Term Depression
                                                    1. Induction protocols
                                                      1. Low-frequency stimulation
                                                        1. Paired-pulse protocols
                                                        2. Molecular mechanisms
                                                          1. Metabotropic glutamate receptors
                                                            1. Calcium signaling
                                                              1. Protein phosphatases
                                                              2. Expression mechanisms
                                                                1. AMPA receptor internalization
                                                                  1. Spine shrinkage
                                                                2. Metaplasticity
                                                                  1. Plasticity of plasticity
                                                                    1. Sliding thresholds
                                                                      1. BCM theory
                                                                    2. Hebbian Learning
                                                                      1. Fire Together Wire Together Principle
                                                                        1. Correlation-based learning
                                                                          1. Activity-dependent plasticity
                                                                          2. Covariance-Based Learning Rules
                                                                            1. Covariance detection
                                                                              1. Decorrelation learning
                                                                              2. Correlation-Based Learning Rules
                                                                                1. Correlation functions
                                                                                  1. Temporal correlations
                                                                                  2. Competitive Hebbian learning
                                                                                    1. Winner-take-all dynamics
                                                                                      1. Feature competition
                                                                                      2. BCM Rule
                                                                                        1. Sliding threshold
                                                                                          1. Selectivity development
                                                                                        2. Spike-Timing-Dependent Plasticity
                                                                                          1. Causal Spike Pairing
                                                                                            1. Pre-before-post timing
                                                                                              1. Potentiation window
                                                                                              2. Anti-Causal Spike Pairing
                                                                                                1. Post-before-pre timing
                                                                                                  1. Depression window
                                                                                                  2. STDP Learning Windows
                                                                                                    1. Temporal precision
                                                                                                      1. Asymmetric windows
                                                                                                        1. Symmetric windows
                                                                                                        2. Mathematical models of STDP
                                                                                                          1. Exponential kernels
                                                                                                            1. Power-law kernels
                                                                                                              1. Triplet rules
                                                                                                              2. Functional consequences
                                                                                                                1. Temporal sequence learning
                                                                                                                  1. Causality detection
                                                                                                                    1. Competitive dynamics
                                                                                                                  2. Homeostatic Plasticity
                                                                                                                    1. Synaptic Scaling
                                                                                                                      1. Global scaling mechanisms
                                                                                                                        1. Activity sensors
                                                                                                                          1. Scaling factors
                                                                                                                          2. Intrinsic Plasticity
                                                                                                                            1. Excitability regulation
                                                                                                                              1. Ion channel regulation
                                                                                                                                1. Firing rate homeostasis
                                                                                                                                2. Network stability mechanisms
                                                                                                                                  1. Excitation-inhibition balance
                                                                                                                                    1. Critical dynamics
                                                                                                                                      1. Avalanche dynamics

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                                                                                                                                  6. Neural Coding