Cancer Genomics

  1. Clinical Applications
    1. Diagnostic Applications
      1. Molecular Diagnosis
        1. Tumor Classification
          1. Subtype Identification
            1. Differential Diagnosis
            2. Prognostic Applications
              1. Risk Stratification
                1. Outcome Prediction
                  1. Treatment Planning
                  2. Hereditary Cancer Assessment
                    1. Germline Testing
                      1. Family Risk Assessment
                        1. Genetic Counseling
                      2. Therapeutic Applications
                        1. Targeted Therapy Selection
                          1. Biomarker-Driven Treatment
                            1. Companion Diagnostics
                              1. Resistance Mechanisms
                              2. Immunotherapy Applications
                                1. Tumor Mutational Burden
                                  1. Microsatellite Instability
                                    1. Neoantigen Prediction
                                    2. Pharmacogenomics
                                      1. Drug Metabolism
                                        1. Toxicity Prediction
                                          1. Dosing Optimization
                                        2. Monitoring Applications
                                          1. Treatment Response Monitoring
                                            1. Circulating Tumor DNA
                                              1. Imaging Biomarkers
                                                1. Functional Assessments
                                                2. Minimal Residual Disease Detection
                                                  1. Sensitive Detection Methods
                                                    1. Clinical Validation
                                                      1. Treatment Decisions
                                                      2. Recurrence Monitoring
                                                        1. Early Detection Strategies
                                                          1. Surveillance Protocols
                                                            1. Intervention Timing
                                                          2. Liquid Biopsies
                                                            1. Circulating Tumor DNA
                                                              1. Detection Technologies
                                                                1. Clinical Applications
                                                                  1. Analytical Considerations
                                                                  2. Circulating Tumor Cells
                                                                    1. Isolation Methods
                                                                      1. Characterization Approaches
                                                                        1. Clinical Utility
                                                                        2. Exosomes and Extracellular Vesicles
                                                                          1. Isolation Techniques
                                                                            1. Molecular Profiling
                                                                              1. Biomarker Potential
                                                                            2. Precision Medicine Implementation
                                                                              1. Clinical Decision Support
                                                                                1. Genomic Interpretation
                                                                                  1. Treatment Recommendations
                                                                                    1. Evidence Integration
                                                                                    2. Molecular Tumor Boards
                                                                                      1. Multidisciplinary Review
                                                                                        1. Case Discussion
                                                                                          1. Treatment Planning
                                                                                          2. Clinical Trial Matching
                                                                                            1. Genomic Eligibility
                                                                                              1. Biomarker Stratification
                                                                                                1. Patient Selection

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                                                                                            5. Cancer Genomic Landscapes

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                                                                                            7. Major Resources and Databases