Behavioral Genetics

  1. Research Methodologies
    1. Quantitative Genetic Approaches
      1. Family Studies
        1. Design Principles
          1. Pedigree Construction
            1. Phenotype Assessment
              1. Statistical Analysis Methods
              2. Familial Aggregation Analysis
                1. Concordance Rates
                  1. Correlation Coefficients
                    1. Recurrence Risk Ratios
                    2. Limitations and Confounding Factors
                      1. Shared Environment Confounds
                        1. Assortative Mating Effects
                          1. Population Stratification
                        2. Twin Studies
                          1. Theoretical Foundation
                            1. Classical Twin Method Logic
                              1. Assumptions and Validity
                                1. Variance Decomposition
                                2. Twin Types and Zygosity
                                  1. Monozygotic Twins
                                    1. Dizygotic Twins
                                      1. Zygosity Determination Methods
                                      2. Heritability Estimation
                                        1. Falconer's Formula
                                          1. Structural Equation Modeling
                                            1. Biometric Model Fitting
                                            2. Equal Environments Assumption
                                              1. Definition and Importance
                                                1. Empirical Testing Methods
                                                  1. Violations and Consequences
                                                  2. Special Twin Designs
                                                    1. Twins Reared Apart
                                                      1. Co-twin Control Method
                                                        1. Discordant Twin Analysis
                                                      2. Adoption Studies
                                                        1. Design Logic and Rationale
                                                          1. Genetic vs. Environmental Separation
                                                            1. Natural Experiment Concept
                                                            2. Study Designs
                                                              1. Adoptee Studies
                                                                1. Adoptive Parent Studies
                                                                  1. Cross-fostering Studies
                                                                  2. Analysis Methods
                                                                    1. Parent-Offspring Correlations
                                                                      1. Sibling Correlations
                                                                        1. Path Analysis
                                                                        2. Methodological Issues
                                                                          1. Selective Placement
                                                                            1. Prenatal Environment Effects
                                                                              1. Gene-Environment Correlation
                                                                            2. Extended Family Designs
                                                                              1. Multi-generational Studies
                                                                                1. Half-sibling Studies
                                                                                  1. Step-family Studies
                                                                                    1. Blended Family Analyses
                                                                                  2. Molecular Genetic Methods
                                                                                    1. Linkage Analysis
                                                                                      1. Principles of Genetic Linkage
                                                                                        1. Recombination and Map Distance
                                                                                          1. Linkage Disequilibrium
                                                                                          2. Parametric Linkage Analysis
                                                                                            1. LOD Score Method
                                                                                              1. Theta Estimation
                                                                                                1. Significance Thresholds
                                                                                                2. Non-parametric Linkage Analysis
                                                                                                  1. Affected Sib-pair Method
                                                                                                    1. Identity by Descent Analysis
                                                                                                    2. Limitations for Complex Traits
                                                                                                      1. Genetic Heterogeneity
                                                                                                        1. Reduced Penetrance
                                                                                                          1. Phenocopy Effects
                                                                                                        2. Association Studies
                                                                                                          1. Study Design Principles
                                                                                                            1. Case-Control Design
                                                                                                              1. Cohort Design
                                                                                                                1. Cross-sectional Design
                                                                                                                2. Candidate Gene Studies
                                                                                                                  1. Gene Selection Strategies
                                                                                                                    1. Functional Variants
                                                                                                                      1. Pathway-based Approaches
                                                                                                                        1. Replication Requirements
                                                                                                                        2. Genome-Wide Association Studies
                                                                                                                          1. Study Design and Power
                                                                                                                            1. Genotyping Technologies
                                                                                                                              1. Quality Control Procedures
                                                                                                                                1. Population Structure Control
                                                                                                                                  1. Statistical Analysis Methods
                                                                                                                                    1. Multiple Testing Correction
                                                                                                                                      1. Result Interpretation
                                                                                                                                      2. Post-GWAS Analysis
                                                                                                                                        1. Fine-mapping Studies
                                                                                                                                          1. Functional Annotation
                                                                                                                                            1. Pathway Analysis
                                                                                                                                              1. Polygenic Risk Scores
                                                                                                                                            2. Sequencing Technologies
                                                                                                                                              1. Whole Genome Sequencing
                                                                                                                                                1. Technology Platforms
                                                                                                                                                  1. Data Processing Pipelines
                                                                                                                                                    1. Variant Calling Methods
                                                                                                                                                      1. Annotation Strategies
                                                                                                                                                      2. Whole Exome Sequencing
                                                                                                                                                        1. Target Enrichment Methods
                                                                                                                                                          1. Coverage Considerations
                                                                                                                                                            1. Variant Prioritization
                                                                                                                                                            2. Targeted Sequencing
                                                                                                                                                              1. Panel Design
                                                                                                                                                                1. Custom Enrichment
                                                                                                                                                                  1. Cost-effectiveness
                                                                                                                                                                2. Functional Genomics
                                                                                                                                                                  1. Gene Expression Analysis
                                                                                                                                                                    1. Microarray Technology
                                                                                                                                                                      1. RNA Sequencing Methods
                                                                                                                                                                        1. Single-cell RNA-seq
                                                                                                                                                                          1. Differential Expression Analysis
                                                                                                                                                                          2. Epigenomic Analysis
                                                                                                                                                                            1. ChIP-seq Methods
                                                                                                                                                                              1. Bisulfite Sequencing
                                                                                                                                                                                1. ATAC-seq
                                                                                                                                                                                  1. Hi-C Analysis
                                                                                                                                                                                  2. Proteomics and Metabolomics
                                                                                                                                                                                    1. Mass Spectrometry Methods
                                                                                                                                                                                      1. Protein Quantification
                                                                                                                                                                                        1. Metabolic Profiling
                                                                                                                                                                                          1. Multi-omics Integration

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                                                                                                                                                                                    1. Foundations of Behavioral Genetics

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                                                                                                                                                                                    3. Gene-Environment Interplay